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Merck
CN

D7000

Deoxycorticosterone acetate

synthetic (organic), ≥98% (HPLC), mineralocorticoid and glucocorticoid, powder

Synonym(s):

11-Deoxycorticosterone acetate, 21-Acetoxy-4-pregnene-3,20-dione, 21-Acetoxyprogesterone, 21-Hydroxy-4-pregnene-3,20-dione 21-acetate, 21-Hydroxyprogesterone 21-acetate, 4-Pregnen-21-ol-3,20-dione 21-acetate, Cortexone acetate, DOC acetate

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About This Item

Empirical Formula (Hill Notation):
C23H32O4
CAS Number:
56-47-3
Molecular Weight:
372.50
NACRES:
NA.77
PubChem Substance ID:
24894065
UNSPSC Code:
12352200
EC Number:
200-275-9
MDL number:
MFCD00003660
Beilstein/REAXYS Number:
2570798
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
200

Key Documents

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Product Name

Deoxycorticosterone acetate,

InChI key

VPGRYOFKCNULNK-ACXQXYJUSA-N

InChI

1S/C23H32O4/c1-14(24)27-13-21(26)20-7-6-18-17-5-4-15-12-16(25)8-10-22(15,2)19(17)9-11-23(18,20)3/h12,17-20H,4-11,13H2,1-3H3/t17-,18-,19-,20+,22-,23-/m0/s1

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@]([H])(CC[C@@]24[H])C(=O)COC(C)=O

biological source

synthetic (organic)

sterility

non-sterile

assay

≥98% (HPLC)

form

powder

solubility

H2O: insoluble
acetone: soluble (1 in 30)
alcohol: soluble (1 in 50)
chloroform: freely soluble
dioxane: slightly soluble
vegetable oils: slightly soluble

shipped in

ambient

storage temp.

room temp

Quality Level

200

Gene Information

human ... NR3C2(4306)

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Application

Deoxycorticosterone acetate has been used to induce hypertensive pregnancy. It has also been used to investigate the effect of low epicatechin dosing on the cardiovascular function of deoxycorticosterone acetate (DOCA)-salt hypertensive rats.

General description

Deoxycorticosterone acetate is an endogenous neurosteroid found in brain and peripheral circulation, which is produced by progesterone. It is both a mineralocorticoid and a glucocorticoid. It is used to treat adrenocortical insufficiency or Addison′s disease. Deoxycorticosterone acetate improves insulin sensitivity. It acts as a precursor to glucocorticoid corticosterone and the GABAergic neuroactive steroid (3α,5α)-3,21-dihydroxypregnan-20-one.

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

涉药品监管产品
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Certificates of Analysis (COA)

Lot/Batch Number
0000181090
0000181090
0000395632
0000340896
0000211306

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Placental nitric oxide formation and endothelium-dependent vasodilation underlie pravastatin effects against angiogenic imbalance, hypertension in pregnancy and intrauterine growth restriction
Chimini JS, et al.
Basic and Clinical Pharmacology and Toxicology (2018)
The mislabelling of deoxycorticosterone: making sense of corticosteroid structure and function.
Vinson GP
The Journal of Endocrinology, 211(1), 3-16 (2011)
Douglas Jackson et al.
Molecules (Basel, Switzerland), 23(7) (2018-06-23)
(−)-Epicatechin (E) is a flavanol found in green tea and cocoa and has been shown to attenuate tumour necrosis factor alpha (TNF-α)-mediated inflammation, improve nitric oxide levels, promote endothelial nitric oxide synthase (eNOS) activation and inhibit NADPH oxidase. This study
(-)-Epicatechin Reduces Blood Pressure and Improves Left Ventricular Function and Compliance in Deoxycorticosterone Acetate-Salt Hypertensive Rats
Jackson D, et al.
Molecules (Basel), 23(7), 1511-1511 (2018)
Genetic analysis of the neurosteroid deoxycorticosterone and its relation to alcohol phenotypes: identification of QTLs and downstream gene regulation
Porcu P, et al.
PLoS ONE, 6(4), e18405-e18405 (2011)
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