D7321
Diosmetin
Synonym(s):
3′,5,7-Trihydroxy-4′-methoxyflavone, 4′-Methylluteolin, 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-one, Luteolin 4′-methyl ether
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About This Item
Empirical Formula (Hill Notation):
C16H12O6
CAS Number:
Molecular Weight:
300.26
UNSPSC Code:
12352205
NACRES:
NA.25
PubChem Substance ID:
EC Number:
208-291-8
Beilstein/REAXYS Number:
294492
MDL number:
assay
≥98% (HPLC)
Quality Segment
form
powder
color
light yellow to yellow
solubility
DMSO: 1 mg/mL, clear, faintly yellow to greenish-yellow
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
2-8°C
SMILES string
COc1ccc(cc1O)C2=CC(=O)c3c(O)cc(O)cc3O2
InChI
1S/C16H12O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-7,17-19H,1H3
InChI key
MBNGWHIJMBWFHU-UHFFFAOYSA-N
General description
Diosmetin is a methylated aglycone flavone of diosmin. It is present abundantly in citrus fruits, Olea europaea L. (olive tree) leaves, and in the legume of Acacia farnesiana tree.
Application
Diosmetin has been used to test its protective effects on chronic stress memory and cognitive impairment in mice model.
Biochem/physiol Actions
Diosmetin exhibits anti-inflammatory, anti-cancer, antimicrobial, phytoestrogenic, and neuroprotective properties. It displays cytoprotective effects against lipopolysaccharide (LPS)-induced acute lung injury (ALI) by inhibiting nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP3) inflammasome and activating nuclear factor erythroid 2–related factor 2 (Nrf2).
Flavonoid from Citrus limon. Antioxidant. Inhibits carcinogen activation by inhibiting the CYP1A1 enzyme.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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