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About This Item
Empirical Formula (Hill Notation):
C10H16N5O12P3
CAS Number:
Molecular Weight:
491.18
MDL number:
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.51
Quality Level
Assay
≥90% (HPLC)
form
powder
solubility
water: 5 mg/mL, clear, colorless
storage temp.
−20°C
SMILES string
[Na+].OP([O-])(=O)OP(O)(=O)OP(O)(=O)OC[C@@H]1CC[C@@H](O1)n2cnc3C(=O)NC(=N)Nc23
InChI
1S/C10H16N5O12P3.Na/c11-10-13-8-7(9(16)14-10)12-4-15(8)6-2-1-5(25-6)3-24-29(20,21)27-30(22,23)26-28(17,18)19;/h4-6H,1-3H2,(H,20,21)(H,22,23)(H2,17,18,19)(H3,11,13,14,16);/q;+1/p-1/t5-,6+;/m0./s1
InChI key
XCOBCPBPAINELA-RIHPBJNCSA-M
Gene Information
human ... HRAS(3265)
Related Categories
Application
2′,3′-Dideoxyguanosine 5′-triphosphate (ddGTP) is use as a chain terminator inhibitor and a inhibitor of telomerase(s).
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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H Pelemans et al.
Molecular pharmacology, 57(5), 954-960 (2000-04-25)
Trp-229 is part of the non-nucleoside reverse transcriptase inhibitor (NNRTI)-binding pocket of HIV type 1 (HIV-1) reverse transcriptase (RT), and is also part of the "primer grip" of HIV-1 RT. Using site-directed mutagenesis, seven RT mutants were constructed bearing the
H Jonckheere et al.
Journal of virological methods, 61(1-2), 113-125 (1996-09-01)
Many bacterial expression systems have been developed to study the reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1). This enzyme exists in the virions as a heterodimer of a 66 kDa (p66) subunit and a 51 kDa (p51)
Joeri Auwerx et al.
Molecular pharmacology, 65(1), 244-251 (2004-01-15)
To map the determinants of the lack of susceptibility of feline immunodeficiency virus (FIV) reverse transcriptase (RT) to anti human immunodeficiency virus type 1 (HIV-1) non-nucleoside RT inhibitors (NNRTIs), a variety of chimeric HIV-1/FIV RTs were constructed. The majority of
Tadamasa Sasaki et al.
The Plant journal : for cell and molecular biology, 47(5), 802-810 (2006-07-22)
RNA editing is found in various transcripts from land plant chloroplasts. In tobacco chloroplasts, C-to-U conversion occurs at 36 specific sites including two sites identified in this work. Our RNA editing assay system using chloroplast extracts facilitated biochemical analyses of
H Jonckheere et al.
The Journal of biological chemistry, 269(41), 25255-25258 (1994-10-14)
Determination of the three-dimensional structure of the human immunodeficiency virus type-1 (HIV-1) reverse transcriptase (RT) has indicated a totally different folding for the 51-kDa subunit (p51) than for the 66-kDa subunit (p66). The polymerase catalytic site is located on the
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