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Merck
CN

D7441

Daltroban

>98% (HPLC)

Synonym(s):

4-[2-[(4-Chlorophenylsulfonyl)amino]ethyl]benzeneacetic acid, BM-13505, SKF-96148

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About This Item

Empirical Formula (Hill Notation):
C16H16ClNO4S
CAS Number:
79094-20-5
Molecular Weight:
353.82
NACRES:
NA.77
PubChem Substance ID:
24724468
UNSPSC Code:
12352200
MDL number:
MFCD00868295
Assay:
>98% (HPLC)
Form:
solid
Quality level:
100

Key Documents

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Product Name

Daltroban, >98% (HPLC)

InChI key

IULOBWFWYDMECP-UHFFFAOYSA-N

SMILES string

OC(=O)Cc1ccc(CCNS(=O)(=O)c2ccc(Cl)cc2)cc1

InChI

1S/C16H16ClNO4S/c17-14-5-7-15(8-6-14)23(21,22)18-10-9-12-1-3-13(4-2-12)11-16(19)20/h1-8,18H,9-11H2,(H,19,20)

assay

>98% (HPLC)

form

solid

color

white

mp

132.5-137.4 °C (lit.)

solubility

DMSO: soluble 22 mg/mL

Quality Level

100

Gene Information

human ... TBXA2R(6915)

Biochem/physiol Actions

Selective thromboxane A2 receptor antagonist

Features and Benefits

This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

General description

Exerts protective effects on brain infarction, heart cell injury due to hypoxia and hypoglycemia and lowers serum CPK activity.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
063K4608

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D Walmrath et al.
American journal of respiratory and critical care medicine, 154(2 Pt 1), 460-468 (1996-08-01)
Both endotoxin (lipopolysaccharides of gram-negative bacteria; LPS) and bacterial exotoxins may induce pulmonary microcirculatory disturbances when infused into the lung vasculature, and synergism between these types of microbial challenge has recently been noted. We now asked whether a bronchoalveolar LPS
T Tanaka et al.
European journal of pharmacology, 357(1), 53-60 (1998-10-27)
We investigated the pharmacological characteristics of Z-335 ((+/-)-sodium[2-[4-(chlorophenylsulfonylaminomethyl)indan-5-yl]ace tate monohydrate), a new indan derivative. Z-335 inhibited the specific binding of [3H]SQ-29548 to human platelets and guinea pig platelet membranes. The IC50 values of Z-335 for human platelets and guinea pig
M Rathaus et al.
Clinical science (London, England : 1979), 88(6), 623-627 (1995-06-01)
1. In previous works we have described the development of hypertension and aggravation of proteinuria in rats who became pregnant after the administration of Adriamycin. This was associated with an increase in the glomerular thromboxane B2-prostaglandin E2 ratio. 2. To
Sabine Pestel et al.
Biochemical pharmacology, 66(4), 643-652 (2003-08-09)
Prostanoids, i.e. prostaglandins and thromboxane, regulate liver-specific functions both in homeostasis and during defense reactions. For example, prostanoids are released from Kupffer cells, the resident liver macrophages, in response to the inflammatory mediator anaphylatoxin C5a, and mediate an enhanced glucose
Anna K Leal et al.
American journal of physiology. Heart and circulatory physiology, 301(5), H2140-H2146 (2011-08-23)
Cyclooxygenase metabolites stimulate or sensitize group III and IV muscle afferents, which comprise the sensory arm of the exercise pressor reflex. The thromboxane (TP) receptor binds several of these metabolites, whose concentrations in the muscle interstitium are increased by exercise
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