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Merck
CN

D7441

Daltroban

>98% (HPLC)

Synonym(s):

4-[2-[(4-Chlorophenylsulfonyl)amino]ethyl]benzeneacetic acid, BM-13505, SKF-96148

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About This Item

Empirical Formula (Hill Notation):
C16H16ClNO4S
CAS Number:
79094-20-5
Molecular Weight:
353.82
NACRES:
NA.77
PubChem Substance ID:
24724468
UNSPSC Code:
12352200
MDL number:
MFCD00868295
Assay:
>98% (HPLC)
Form:
solid
Quality level:
100

Key Documents

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InChI key

IULOBWFWYDMECP-UHFFFAOYSA-N

SMILES string

OC(=O)Cc1ccc(CCNS(=O)(=O)c2ccc(Cl)cc2)cc1

InChI

1S/C16H16ClNO4S/c17-14-5-7-15(8-6-14)23(21,22)18-10-9-12-1-3-13(4-2-12)11-16(19)20/h1-8,18H,9-11H2,(H,19,20)

assay

>98% (HPLC)

form

solid

color

white

mp

132.5-137.4 °C (lit.)

solubility

DMSO: soluble 22 mg/mL

Quality Level

100

Gene Information

human ... TBXA2R(6915)

General description

Exerts protective effects on brain infarction, heart cell injury due to hypoxia and hypoglycemia and lowers serum CPK activity.

Biochem/physiol Actions

Selective thromboxane A2 receptor antagonist

Features and Benefits

This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
063K4608

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Milena Koleva et al.
Gastroenterology, 122(3), 697-708 (2002-03-05)
In normal rat liver, anaphylatoxin C5a induces glucose output from hepatocytes indirectly via prostanoids released from Kupffer cells. Correspondingly, it was found that hepatocytes, in contrast to Kupffer cells, did not express C5a receptors. Lipopolysaccharide (LPS) has been reported to
Sabine Pestel et al.
Laboratory investigation; a journal of technical methods and pathology, 83(12), 1733-1741 (2003-12-24)
Various inflammatory stimuli such as anaphylatoxin C5a, zymosan, and lipopolysaccharides (LPSs) have been reported both to enhance glucose output in the perfused rat liver and to induce prostanoid (ie, prostaglandin and thromboxane) release from Kupffer cells, the resident liver macrophages.
M Shimazawa et al.
European journal of pharmacology, 328(2-3), 183-189 (1997-06-11)
The antithrombotic effect of desethyl KBT-3022, which is the main active metabolite of the new antiplatelet agent, KBT-3022 (ethyl 2-[4,5-bis(4-methoxyphenyl)thiazol-2-yl] pyrrol-1-ylacetate; a cyclooxygenase inhibitor), was determined using a photochemically induced arterial thrombosis model in the rat femoral artery. Pretreatment with
A Rizzo et al.
The American journal of physiology, 268(5 Pt 2), H1954-H1958 (1995-05-01)
The effects of platelet-activating factor (PAF) on vascular resistance and capillary permeability were studied in the isolated rat hindquarter. Six groups were studied (n = 30): control; PAF alone (1.4 microM); and PAF (1.4 microM) pretreated with ibuprofen (30 mg/kg)
F Bertolino et al.
Naunyn-Schmiedeberg's archives of pharmacology, 356(4), 462-466 (1998-01-24)
We sought to determine whether the intrinsic pulmonary hypertensive activity of the purported thromboxane A2/prostanoid (TP) receptor antagonist, daltroban, was mediated by TP receptors, using the high efficacy TP receptor agonist, U-46619, and the silent TP receptor antagonist, SQ 29,548.
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