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Merck
CN

D7571

Dimaprit dihydrochloride

≥98% (NMR)

Synonym(s):

Carbamimidothioic acid, 3-(dimethylamino)propyl ester, hydrochloride (1:2), Dimaprit-2HCl

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About This Item

Empirical Formula (Hill Notation):
C6H15N3S · 2HCl
CAS Number:
23256-33-9
Molecular Weight:
234.19
NACRES:
NA.77
PubChem Substance ID:
329798854
UNSPSC Code:
12352200
MDL number:
MFCD00069260

Key Documents

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Product Name

Dimaprit dihydrochloride, ≥98% (NMR)

InChI

1S/C6H15N3S.2ClH/c1-9(2)4-3-5-10-6(7)8;;/h3-5H2,1-2H3,(H3,7,8);2*1H

SMILES string

Cl.Cl.CN(C)CCCSC(N)=N

InChI key

DFWCPLGXFMSUCW-UHFFFAOYSA-N

assay

≥98% (NMR)

form

powder

color

white to off-white

solubility

H2O: ≥50 mg/mL

originator

Roche

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

Selective histamine receptor H2 agonist.
The histamine H2 receptor influences various cardiovascular responses, including vasodilation and cardiac rhythm, regulates gastric acid secretion, and also plays a role in the immune system by inhibiting antibody production, T cell proliferation and cytokine production. Histamine receptors are members of the GPCR family, and H2 mediates cell signaling via internalization and interaction with the GTPase dynamin.

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
090M4726V
090M4726

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Tetsuya Tachibana et al.
Domestic animal endocrinology, 66, 57-63 (2018-11-26)
Infectious conditions are associated with reduced food passage through the digestive tract in both mammals and chicks; however, the precise mechanism mediating this response in chicks remains unclear. The purpose of the present study was to determine if mast cells
Hamid Ghasemi et al.
Pharmacological reports : PR, 69(6), 1393-1401 (2017-11-18)
Histamine and opiate systems contribute to supraspinal processing of pain. In the present study, we investigated the effects of microinjection of histamine and agonists and antagonists of histamine H The thalamic ventral posterolateral nuclei were bilaterally implanted with two guide
Binu Kundukad et al.
Biophysical journal, 99(6), 1906-1915 (2010-09-23)
The flow properties of DNA are important for understanding cell division and, indirectly, cancer therapy. DNA topology controlling enzymes such as topoisomerase II are thought to play an essential role. We report experiments showing how double-strand passage facilitated by topoisomerase II
J Sethi et al.
Neuroscience, 217, 84-95 (2012-05-15)
Histamine acts centrally to increase energy expenditure and reduce body weight by mechanisms not fully understood. It has been suggested that in the obese state hypothalamic histamine signaling is altered. Previous studies have also shown that histamine acting in the
J Kitanaka et al.
Neuroscience, 147(3), 765-777 (2007-06-16)
The administration of methamphetamine (METH, 10 mg/kg, i.p.) to male ICR mice induced stereotyped behavior consisting of nail and/or wood chip biting (86.0%), continuous sniffing (12.0%), head bobbing (1.1%), and circling (1.0%) during the observation period of 1 h. Pretreatment
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