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D8446

P7C3

Name: P7C3
Brand: SIGMA

≥98% (HPLC)

Synonym(s):

3,6-Dibromo-a-[(phenylamino)methyl]-9H-carbazole-9-ethanol

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About This Item

Empirical Formula (Hill Notation):

C₂₁H₁₈Br₂N₂O

CAS Number:

301353-96-8

Molecular Weight:

474.19

NACRES:

NA.25

PubChem Substance ID:

329798864

UNSPSC Code:

12352203

MDL number:

MFCD00572918

Assay:

≥98% (HPLC)

Form:

powder

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Properties

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: 34 mg/mL

storage temp.

2-8°C

SMILES string

OC(CNc1ccccc1)Cn2c3ccc(Br)cc3c4cc(Br)ccc24

InChI

1S/C21H18Br2N2O/c22-14-6-8-20-18(10-14)19-11-15(23)7-9-21(19)25(20)13-17(26)12-24-16-4-2-1-3-5-16/h1-11,17,24,26H,12-13H2

InChI key

FZHHRERIIVOATI-UHFFFAOYSA-N

Description

Application

P7C3 is an aminopropyl carbazole agent with proneurogenic and neuroprotective properties in newborn neural precursor cells of the dentate gyrus. Its analogs may be used in neurodegenerative disease research to study the process of neurogenesis in brain regions such as the subgranular zone of the hippocampal dentate gyrus. P7C3 and its analogs may be used to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as potential drug for the treatment of condition such as Alzheimer′s disease, Parkinson′s disease, amyotrophic lateral sclerosis and traumatic brain injury.

Biochem/physiol Actions

P7C3 is a proneurogenic, neuroprotective enhancer of neuron formation.

P7C3 is neurogenic and protects new neurons against apoptosis. These activities may be related to its capacity to protect mitochondrial integrity.

Degeneration of the hippocampus is an early manifestation of Alzheimer′s disease. P7C3 promotes neurogenesis in the subgranular zone of the hippocampal dentate gyrus, the site of normal neurogenesis in adult mammals, making it an important lead compound in development of new Alzheimer′s treatments.