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D9160

1-Deoxymannojirimycin hydrochloride

Name: 1-Deoxymannojirimycin hydrochloride
Brand: SIGMA

Synonym(s):

1-Deoxymannojirimycin HCl, 1,5-Dideoxy-1,5-imino-D-mannitol hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₆H₁₃NO₄ · HCl

CAS Number:

73465-43-7

Molecular Weight:

199.63

NACRES:

NA.76

PubChem Substance ID:

24894265

UNSPSC Code:

51102829

MDL number:

MFCD00083611

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form

powder

Quality Level

200

color

white to off-white

solubility

H₂O: 10 mg/mL

antibiotic activity spectrum

viruses

mode of action

enzyme | inhibits

storage temp.

2-8°C

SMILES string

Cl.OC[C@H]1NC[C@@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C6H13NO4.ClH/c8-2-3-5(10)6(11)4(9)1-7-3;/h3-11H,1-2H2;1H/t3-,4-,5-,6-;/m1./s1

InChI key

ZJIHMALTJRDNQI-MVNLRXSJSA-N

Related Categories

Antibiotics

Biochemicals

Cell Culture Supplements & Reagents

Chemistry & Biochemicals

General description

Chemical structure: glucosamine

Application

1-Deoxymannojirimycin (DMM) hydrochloride is an inhibitor of N-linked glycosylation and has antiviral activity. Derivatives of deoxymannojirimycin may have anti-HIV activity. It has been used for treatment of T lymphocytes and to study it′s effect on allogeneic cytotoxic T lymphocytes (CTL). It is used for studies on Golgi-mediated glycoprotein processing.

Biochem/physiol Actions

1-Deoxymannojirimycin is a mannosidase I inhibitor, alters cell-surface complex carbohydrate structure as assayed by PHA-L binding, and increases high mannose structures as indicated by the increased Con-A binding.

Selectively inhibits Golgi associated α(1→2) mannosidase and for studies on Golgi-mediated glycoprotein processing.

pictograms

GHS07

signalword

Warning

hcodes

H302 + H312 + H332

pcodes

P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

涉药品监管产品

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Certificates of Analysis (COA)

Lot/Batch Number

0000506793

0000409195

0000246377

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Glycosylation of native MHC class Ia molecules is required for recognition by allogeneic cytotoxic T lymphocytes.

E U Bagriaçik et al.

Glycobiology, 6(4), 413-421 (1996-06-01)

The question whether or not target cell N-linked carbohydrate participates in cytotoxic T lymphocyte (CTL) mediated cytolysis has been in contention for well over a decade. Much of the evidence supporting a role for N-linked carbohydrate stems from the treatment

Impact of cell culture media additives on IgG glycosylation produced in Chinese hamster ovary cells.

Janike Ehret et al.

Biotechnology and bioengineering, 116(4), 816-830 (2018-12-16)

Glycosylation is a key critical quality attribute for monoclonal antibodies and other recombinant proteins because of its impact on effector mechanisms and half-life. In this study, a variety of compounds were evaluated for their ability to modulate glycosylation profiles of

Global Trade Item Number

SKU	GTIN
D9160-5MG	04061832991078
D9160-10MG	04061832991061
D9160-1MG	04061826674581

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