D9571
Dolasetron mesylate hydrate
≥98% (HPLC), powder
Synonym(s):
Anzemet hydrate, Dolasetron methanesulfonate hydrate
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About This Item
Empirical Formula (Hill Notation):
C19H20N2O3 · CH4O3S · xH2O
CAS Number:
Molecular Weight:
420.48 (anhydrous basis)
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to off-white
solubility
H2O: >30 mg/mL
originator
Sanofi Aventis
storage temp.
2-8°C
SMILES string
O.CS(O)(=O)=O.O=C1CN2[C@@H]3C[C@H](C[C@H]2CC1C3)OC(=O)c4c[nH]c5ccccc45
InChI
1S/C19H20N2O3.CH4O3S.H2O/c22-18-10-21-12-5-11(18)6-13(21)8-14(7-12)24-19(23)16-9-20-17-4-2-1-3-15(16)17;1-5(2,3)4;/h1-4,9,11-14,20H,5-8,10H2;1H3,(H,2,3,4);1H2/t11?,12-,13+,14+;;
InChI key
QTFFGPOXNNGTGZ-BHSFMSKKSA-N
Biochem/physiol Actions
Dolasetron mesylate hydrate is a highly selective serotonin 5-HT3 receptor antagonist.
Dolasetron mesylate hydrate is a highly specific and selective serotonin 5-HT3 receptor antagonist, not shown to have activity at other known serotonin receptors and with low affinity for dopamine receptors.
Features and Benefits
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Articles
We offer many products related to serotonin receptors for your research needs.
我们提供许多血清素受体相关产品，满足您的各类研究需求。
Swen N Piper et al.
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 36(3), 173-179 (2008-03-21)
The aim of this study was to evaluate the efficacy of dolasetron and droperidol (DHB) for preventing postoperative nausea and vomiting (PONV) in patients undergoing surgery for prognathism. In a randomised, placebo-controlled, double-blind trial, the efficacy of 12.5 mg dolasetron
D Rüsch et al.
Anaesthesia, 62(8), 810-817 (2007-07-20)
It is not known whether dexamethasone increases the effectiveness of anti-emetics when given to treat postoperative nausea and vomiting (PONV). In a randomised study, 242 patients who were experiencing PONV received dolasetron and placebo, haloperidol and placebo, dolasetron and dexamethasone
Sadeq A Quraishi et al.
Journal of clinical anesthesia, 23(4), 297-302 (2011-06-15)
To investigate whether a common single nucleotide polymorphism (SNP), rs10494366, is associated with significant prolongation of the QTc interval following administration of 5-HT(3)-receptor antagonists in the perioperative setting. Post-hoc analysis of deoxyribonucleic acid (DNA) samples and electrocardiographic (ECG) data from
Global Trade Item Number
| SKU | GTIN |
|---|---|
| D9571-50MG | 04061832082042 |
| D9571-10MG | 04061832082035 |