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Merck
CN

D9571

Dolasetron mesylate hydrate

≥98% (HPLC), powder

Synonym(s):

Anzemet hydrate, Dolasetron methanesulfonate hydrate

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About This Item

Empirical Formula (Hill Notation):
C19H20N2O3 · CH4O3S · xH2O
CAS Number:
115956-13-3
Molecular Weight:
420.48 (anhydrous basis)
MDL number:
MFCD30478915
UNSPSC Code:
12352200
PubChem Substance ID:
329798907
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

Key Documents

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SMILES string

O.CS(O)(=O)=O.O=C1CN2[C@@H]3C[C@H](C[C@H]2CC1C3)OC(=O)c4c[nH]c5ccccc45

InChI

1S/C19H20N2O3.CH4O3S.H2O/c22-18-10-21-12-5-11(18)6-13(21)8-14(7-12)24-19(23)16-9-20-17-4-2-1-3-15(16)17;1-5(2,3)4;/h1-4,9,11-14,20H,5-8,10H2;1H3,(H,2,3,4);1H2/t11?,12-,13+,14+;;

InChI key

QTFFGPOXNNGTGZ-BHSFMSKKSA-N

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

H2O: >30 mg/mL

originator

Sanofi Aventis

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

Dolasetron mesylate hydrate is a highly selective serotonin 5-HT3 receptor antagonist.
Dolasetron mesylate hydrate is a highly specific and selective serotonin 5-HT3 receptor antagonist, not shown to have activity at other known serotonin receptors and with low affinity for dopamine receptors.

Features and Benefits

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000205060
0000205061
0000205061
0000205060
031M4708V

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Sarah Turner et al.
Journal of clinical anesthesia, 19(8), 622-625 (2007-12-18)
A 52-year-old woman with hypertension and Graves' disease was scheduled for surgical removal of a meningioma. Intraoperative events were significant for hypotension requiring a vasopressin infusion. Prophylactic dolasetron was administered to the patient before emergence. The patient's trachea was easily
Christopher M Peters et al.
Brain research, 1352, 83-93 (2010-07-20)
The balance between descending inhibition and facilitation is thought to be disturbed in chronic pain states. Increased facilitation by spinally released serotonin has been suggested by demonstration that mechanically evoked neuronal responses of wide dynamic range neurons are inhibited by
Edward B Silberstein
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 49(4), 546-549 (2008-03-18)
The goal of this study was to reduce the salivary symptoms of pain and xerostomia caused by 131I therapy for papillary and follicular thyroid carcinoma. In a single-blind controlled prospective study of 60 patients, we investigated whether pilocarpine, 5 mg
Lauren Trepanier
Journal of feline medicine and surgery, 12(3), 225-230 (2010-03-03)
The control of nausea and vomiting in cats is important in order to prevent the development of food aversion, anorexia (with its associated complications of weight loss and dehydration), and hepatic lipidosis. There are several antiemetic drugs that are clinically
[Pharmacokinetic and pharmacodynamic features of palonosetron].
Armando A Genazzani et al.
Tumori, 94(2), suppl 6-suppl13 (2008-06-21)
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