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D9815

Doxazosin mesylate

Name: Doxazosin mesylate
Brand: SIGMA

≥97% (HPLC), powder

Synonym(s):

1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[4-(1,4-benzodioxan-2-yl)carpiperazin-1-yl)]-6,7-dimethoxyquinazoline mesylate, Doxazosin methanesulfonate

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About This Item

Empirical Formula (Hill Notation):

C₂₃H₂₅N₅O₅ · CH₃SO₃H

CAS Number:

77883-43-3

Molecular Weight:

547.58

NACRES:

NA.77

PubChem Substance ID:

24278398

UNSPSC Code:

12352200

MDL number:

MFCD00216023

Assay:

≥97% (HPLC)

Form:

powder

Quality level:

200

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Quality Level

200

assay

≥97% (HPLC)

form

powder

color

white

SMILES string

CS(O)(=O)=O.COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)C4COc5ccccc5O4

InChI

1S/C23H25N5O5.CH4O3S/c1-30-18-11-14-15(12-19(18)31-2)25-23(26-21(14)24)28-9-7-27(8-10-28)22(29)20-13-32-16-5-3-4-6-17(16)33-20;1-5(2,3)4/h3-6,11-12,20H,7-10,13H2,1-2H3,(H2,24,25,26);1H3,(H,2,3,4)

InChI key

VJECBOKJABCYMF-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)
rat ... Adra1a(29412), Adra1b(24173), Adra1d(29413)

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Biochem/physiol Actions

α₁-adrenoceptor antagonist; relaxes smooth muscles of the prostate

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Efficacy of medical expulsive treatment with doxazosin in pediatric patients.

Sakip Erturhan et al.

Urology, 81(3), 640-643 (2013-01-25)

To evaluate the possible efficacy of an α1 blocker (doxazosin) therapy on the management and disease course in pediatric patients with distal ureteral stones. A total of 45 patients (24 boys and 21 girls) with a single lower ureteral stone

Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.

Cédric M Hysek et al.

Psychopharmacology, 224(3), 363-376 (2012-06-16)

Pupillometry can be used to characterize autonomic drug effects. This study was conducted to determine the autonomic effects of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy), administered alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin, on pupillary function. Infrared pupillometry was

Noradrenergic α₁ receptor antagonist treatment attenuates positive subjective effects of cocaine in humans: a randomized trial.

Thomas F Newton et al.

PloS one, 7(2), e30854-e30854 (2012-02-10)

Preclinical research implicates dopaminergic and noradrenergic mechanisms in mediating the reinforcing effects of drugs of abuse, including cocaine. The objective of this study was to evaluate the impact of treatment with the noradrenergic α(1) receptor antagonist doxazosin on the positive

A small molecule agonist of EphA2 receptor tyrosine kinase inhibits tumor cell migration in vitro and prostate cancer metastasis in vivo.

Aaron Petty et al.

PloS one, 7(8), e42120-e42120 (2012-08-24)

During tumor progression, EphA2 receptor can gain ligand-independent pro-oncogenic functions due to Akt activation and reduced ephrin-A ligand engagement. The effects can be reversed by ligand stimulation, which triggers the intrinsic tumor suppressive signaling pathways of EphA2 including inhibition of

Laparoscopic adrenalectomy, a safe procedure for pheochromocytoma. A retrospective review of clinical series.

Giovanni Conzo et al.

International journal of surgery (London, England), 11(2), 152-156 (2012-12-27)

Minimally invasive adrenalectomy for pheochromocytoma (PCC) is a complex surgical procedure especially because of the haemodynamic instability due to the excessive secretion of cathecolamines, which may result in a considerable risk of conversion and complications. By a multicentric retrospective study

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Global Trade Item Number

SKU	GTIN
D9815-50MG	04061833591222
D9815-250MG	04061832090573

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