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E1378

Escin

Name: Escin
Brand: SIGMA

≥95%, powder

Synonym(s):

Aescin

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About This Item

CAS Number:

6805-41-0

NACRES:

NA.25

PubChem Substance ID:

24894403

UNSPSC Code:

12352201

EC Number:

229-880-6

MDL number:

MFCD00076054

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Quality Level

200

biological source

plant (Aesculus chinensis)

assay

≥95%

form

powder

impurities

≤6.0% Water (Karl Fischer)

color

white

solubility

methanol: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

SMILES string

C\C=C(/C)C(=O)OC1[C@H](OC(C)=O)C2(CO)[C@H](O)C[C@]3(C)C(=CCC4C5(C)CCC(O[C@@H]6O[C@@H]([C@@H](O[C@@H]7O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O)[C@H](O)[C@H]6O[C@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)C(O)=O)[C@](C)(CO)C5CCC34C)C2CC1(C)C

InChI

1S/C55H86O24/c1-10-23(2)46(71)79-43-44(72-24(3)60)55(22-59)26(17-50(43,4)5)25-11-12-30-51(6)15-14-32(52(7,21-58)29(51)13-16-53(30,8)54(25,9)18-31(55)61)75-49-41(77-48-38(67)36(65)34(63)28(20-57)74-48)39(68)40(42(78-49)45(69)70)76-47-37(66)35(64)33(62)27(19-56)73-47/h10-11,26-44,47-49,56-59,61-68H,12-22H2,1-9H3,(H,69,70)/b23-10+/t26?,27-,28-,29?,30?,31-,32?,33-,34-,35+,36+,37-,38-,39+,40+,41-,42+,43?,44+,47+,48-,49-,51?,52-,53?,54-,55?/m1/s1

InChI key

AXNVHPCVMSNXNP-YSYFQUGBSA-N

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Related Categories

Biochemicals

Carbohydrates for Biochemical Research

Cell Culture Supplements & Reagents

Chemical Biology

Application

Escin, a natural mixture of triterpenoid saponins isolated from horse chestnut (Aesculus hippocastanum) seeds, is used and studied as a vasoprotective anti-inflammatory, anti-edematous and anti-nociceptive agent. It may be used to study its pharmacokinetics, safety and efficacy as a chemosensitizer and modulator of NF-κ B cell signaling.

Other Notes

To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

pictograms

GHS07

signalword

Warning

hcodes

H302 + H332

pcodes

P261 - P264 - P271 - P301 + P312 - P304 + P340 + P312 - P501

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 2

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Intrathecal landiolol inhibits nociception and spinal c-Fos expression in the mouse formalin test.

Hang Zhao et al.

Canadian journal of anaesthesia = Journal canadien d'anesthesie, 54(3), 201-207 (2007-03-03)

The purpose of this study was to determine if intrathecal landiolol, a beta1-blocker, can modulate formalin-induced nociception and spinal c-Fos expression in mice, in the absence of anesthesia. Thirty-two mice were randomly assigned to one of four groups: the control

Escin, a pentacyclic triterpene, chemosensitizes human tumor cells through inhibition of nuclear factor-kappaB signaling pathway.

Kuzhuvelil B Harikumar et al.

Molecular pharmacology, 77(5), 818-827 (2010-01-28)

Agents that can enhance tumor cell apoptosis and inhibit invasion have potential for the treatment of cancer. Here, we report the identification of escin, a pentacyclic triterpenoid from horse chestnut that exhibits antitumor potential against leukemia and multiple myeloma. Whether

Escin inhibits type I allergic dermatitis in a novel porcine model.

Wolfgang Sipos et al.

International archives of allergy and immunology, 161(1), 44-52 (2012-12-22)

Current standard medications for the treatment of allergic inflammation consist primarily of glucocorticoids and anti-histamines, but adverse side effects or insufficient responsiveness by patient subpopulations illustrate the need for safe and novel alternatives. Thus, there is a demand to develop

Protective effect of aescin from the seeds of Aesculus hippocastanum on liver injury induced by endotoxin in mice.

Na Jiang et al.

Phytomedicine : international journal of phytotherapy and phytopharmacology, 18(14), 1276-1284 (2011-08-02)

To investigate the effect and underlying mechanism of aescin on acute liver injury induced by endotoxin, liver injury was established by injecting lipopolysaccharide (LPS) in mice. Animals were assigned to seven groups: the control group and groups treated with LPS

Comparative pharmacokinetics and the bioavailability of escin Ib and isoescin Ib following the administration of escin, pure escin Ib and isoescin Ib in rats.

Xiu-Jun Wu et al.

Journal of ethnopharmacology, 151(2), 839-845 (2013-12-18)

Adequate pharmacokinetic data of escin, a natural mixture of triterpene saponins used for the treatment of chronic venous insufficiency, hemorrhoids, inflammation and edema, is of special interest in view of the growing use of escin agent in clinical medicine. However

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Global Trade Item Number

SKU	GTIN
E1378-5G	04061833601716
E1378-1G	04061833601709
E1378-10G	04061833601693

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