E1631
β-Estradiol 17-valerate
≥98% (HPLC), powder
Synonym(s):
1,3,5(10)-Estratriene-3,17β-diol 17-pentanote
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About This Item
Empirical Formula (Hill Notation):
C23H32O3
CAS Number:
Molecular Weight:
356.50
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
213-559-2
MDL number:
Beilstein/REAXYS Number:
2480357
Product Name
β-Estradiol 17-valerate, ≥98%
biological source
synthetic
Quality Level
assay
≥98%
form
powder
technique(s)
ELISA: suitable
solubility
acetone: 25 mg/mL, hazy, colorless
shipped in
ambient
storage temp.
room temp
SMILES string
CCCCC(=O)OC1CCC2C3CCc4cc(O)ccc4C3CCC12C
InChI
1S/C23H32O3/c1-3-4-5-22(25)26-21-11-10-20-19-8-6-15-14-16(24)7-9-17(15)18(19)12-13-23(20,21)2/h7,9,14,18-21,24H,3-6,8,10-13H2,1-2H3
InChI key
RSEPBGGWRJCQGY-UHFFFAOYSA-N
General description
β-Estradiol 17-valerate is a synthetic estrogen.
Application
β-Estradiol 17-valerate has been used:
- in an in-vivo assay, to synchronize the estrus cycle in athymic nude mice, to study the effect of recombinant pigment epithelium-derived factor (rPEDF) on induced ectopic fibroid lesions
- to study the influence of ovarian hormones on type II cGMP-dependent protein kinase (Prkg2) expression in mice
- to induce growth of estrogen-dependent tumor cells in athymic nude mice to establish a breast cancer mouse model
Biochem/physiol Actions
Estradiol valerate is observed to be useful for treating menopausal climacteric symptoms. β-Estradiol 17-valerate is used as a source of 17β-estradiol (E2) in in vitro fertilization, hormone replacement therapy, contraceptive drugs, to study reproductive disorders in animal models. It serves as growth promoter in animal farming. β-Estradiol 17-valerate is also used to culture single-sex population among fish. Studies in rats show that β-Estradiol 17-valerate has negative effects on the estrus cycle pattern.
signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 1 - Carc. 2 - Lact. - Repr. 2
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
Regulatory Information
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Kevin Hollevoet et al.
Oncotarget, 9(17), 13623-13636 (2018-03-24)
Antibody gene transfer presents an appealing alternative to conventional antibody protein therapy. This pre-clinical study evaluates the impact of various parameters on the pharmacokinetics and efficacy of in vivo expressed DNA-based anti-HER2 monoclonal antibodies (mAbs), newly engineered and delivered via
Christophe Blockeel et al.
Reproductive biomedicine online, 24(3), 272-280 (2012-02-03)
This randomized controlled trial analyses the ability to control the oocyte retrieval schedule of gonadotrophin-releasing hormone antagonist cycles through the administration of oestradiol valerate during the luteo-follicular transition period prior to the initiation of ovarian stimulation. Eighty-six women undergoing ovarian
Marika Christina Möller et al.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 29(2), 173-176 (2012-10-26)
Both estrogen and testosterone insufficiency has been associated with reduced psychological well-being including fatigue. However, hormonal replacement studies on fatigue are rare. Therefore, we wanted to study the effect of testosterone and estrogen replacement therapy on cognitive fatigue and the
Global Trade Item Number
| SKU | GTIN |
|---|---|
| E1631-1G | 04061833602010 |