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E2375

Emetine dihydrochloride

Name: Emetine dihydrochloride
Brand: SIGMA

RNA polymerase inhibitor

Synonym(s):

6′,7′,10,11-Tetramethoxyemetan dihydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₂₉H₄₀N₂O₄ · 2HCl

CAS Number:

316-42-7

Molecular Weight:

553.56

UNSPSC Code:

12352200

PubChem Substance ID:

24278410

NACRES:

NA.77

MDL number:

MFCD00242944

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Properties

Product Name

Emetine dihydrochloride,

Quality Segment

100

antibiotic activity spectrum

parasites

mode of action

protein synthesis | interferes

storage temp.

2-8°C

SMILES string

[H][C@@]12C[C@H](C[C@@]3([H])NCCC4=C3C=C(OC)C(OC)=C4)[C@@H](CC)CN1CCC5=C2C=C(OC)C(OC)=C5

InChI

1S/C29H40N2O4.2ClH/c1-6-18-17-31-10-8-20-14-27(33-3)29(35-5)16-23(20)25(31)12-21(18)11-24-22-15-28(34-4)26(32-2)13-19(22)7-9-30-24;;/h13-16,18,21,24-25,30H,6-12,17H2,1-5H3;2*1H/t18-,21-,24+,25-;;/m0../s1

InChI key

JROGBPMEKVAPEH-GXGBFOEMSA-N

Description

Application

Emetine dihydrochloride has been used:

as a protein synthesis inhibitor to study its effects on human papillomavirus type 8 E2 protein half-life
to study its effects on the stress granules assembly
as a chain-elongation inhibitor in puromycin assay for protein synthesis

Biochem/physiol Actions

Emetine dihydrochloride is a member of the ipecac alkaloids family. It can mediate inhibition of protein and nucleic acid synthesis. It exhibits antiviral activity against dengue virus infection and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Emetine dihydrochloride exhibits anti-proliferative effects against bladder cancer cells. It also possesses anti-protozoal activity.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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pictograms

GHS06

signalword

Danger

hcodes

H300,H315,H319

pcodes

P264 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338 - P332 + P313

Hazard Classifications

Acute Tox. 1 Oral - Eye Irrit. 2 - Skin Irrit. 2

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

剧毒化学品

监管及禁止进口产品

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Articles

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

Global Trade Item Number

SKU	GTIN
E2375-1G	04061833602577
E2375-500MG	04061833602584
E2375-250MG	04061832270722
E2375-5G	04061833619865