E5139
DL-Ethionine
≥95% (TLC)
Synonym(s):
DL-2-Amino-4-(ethylthio)butyric acid
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About This Item
Linear Formula:
C2H5SCH2CH2CH(NH2)COOH
CAS Number:
Molecular Weight:
163.24
Beilstein/REAXYS Number:
1722529
NACRES:
NA.26
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
200-647-0
MDL number:
Product Name
DL-Ethionine, ≥95% (TLC)
InChI key
GGLZPLKKBSSKCX-UHFFFAOYSA-N
InChI
1S/C6H13NO2S/c1-2-10-4-3-5(7)6(8)9/h5H,2-4,7H2,1H3,(H,8,9)
SMILES string
CCSCCC(N)C(O)=O
assay
≥95% (TLC)
form
powder
color
white to off-white
mp
269 °C
application(s)
cell analysis
storage temp.
−20°C
Quality Level
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Application
- Superoxide dismutase activity as a measure of hepatic oxidative stress in cattle following ethionine administration.: This study evaluates the hepatic oxidative stress in cattle induced by ethionine administration by measuring superoxide dismutase activity. The findings suggest a significant oxidative response, highlighting the role of DL-Ethionine in studying liver oxidative mechanisms (Abd Ellah et al., 2009).
Biochem/physiol Actions
DL-Ethionine is a racemic mixture of the anti-methylation agent L-Ethionine and its enantiomer D-Ethionine. DL-Ethionine is used as a dietary supplement to accelerate cholangiocarcinogenesis in vivo. DL-Ethionine is used to induce oxidative stress in liver to study the levels and activities of anti-oxidative enzymes and compounds such as glutathione.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Janeli Viil et al.
Scientific reports, 7, 40322-40322 (2017-01-14)
Cells with slow proliferation kinetics that retain the nuclear label over long time periods-the label-retaining cells (LRCs)-represent multipotent stem cells in a number of adult tissues. Since the identity of liver LRCs (LLRCs) had remained elusive we utilized a genetic
Mami Furukawa et al.
Anticancer research, 29(10), 4047-4050 (2009-10-23)
To evaluate an involvement of LKB1 gene alteration during pancreatic carcinogenesis, mutations in the LKB1 gene in hamster pancreatic duct adenocarcinomas (PDAs) induced by N-nitrosobis(2-oxopropyl)amine (BOP) were investigated. Female Syrian golden hamsters received 30 mg/kg of BOP followed by repeated
Muneyoshi Kanai et al.
Journal of bioscience and bioengineering, 123(1), 8-14 (2016-08-28)
Sake yeasts are ideally suited for sake making, producing higher levels of ethanol, proliferating at lower temperatures, and producing greater levels of various aromatic components and nutrients than laboratory yeasts. To elucidate the mechanism underlying S-adenosylmethionine (SAM) accumulation in sake
Miku Hirane et al.
Molecular carcinogenesis, 55(11), 1573-1583 (2015-09-18)
Lysophosphatidic acid (LPA) signaling via LPA receptors (LPA1 to LPA6 ) mediates a variety of cellular functions, including cell motility. In the present study, we investigated the effects of LPA receptors on cell motile activity during multi-stage hepatocarcinogenesis in rat
Mahmoud R Abd Ellah et al.
Veterinary journal (London, England : 1997), 182(2), 336-341 (2008-07-01)
The goal of this study was to assess if oxidative stress, as measured by alterations in the concentrations of antioxidant enzymes in the liver and erythrocytes of cattle, could be induced following dl-ethionine administration. Whole blood, serum and liver biopsy
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