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E6527

Elastin, soluble from bovine neck ligament

salt-free, lyophilized powder

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About This Item

CAS Number:
9007-58-3
UNSPSC Code:
12352202
NACRES:
NA.61
EC Number:
232-701-4
MDL number:
MFCD02687372
Form:
salt-free, lyophilized powder
Biological source:
bovine neck ligament

Key Documents

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SMILES string

N1([C@@H](CCC1)C(=O)NC)C(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)CC(C)C)[C@H](CC)C)C(C)C

InChI key

DPUYCSDGMSDKKV-MKBYFEBXSA-N

InChI

1S/C27H48N6O6/c1-9-17(6)23(32-24(36)19(13-15(2)3)30-18(7)34)26(38)29-14-21(35)31-22(16(4)5)27(39)33-12-10-11-20(33)25(37)28-8/h15-17,19-20,22-23H,9-14H2,1-8H3,(H,28,37)(H,29,38)(H,30,34)(H,31,35)(H,32,36)/t17-,19-,20-,22-,23-/m0/s1

biological source

bovine neck ligament

form

salt-free, lyophilized powder

technique(s)

UV/Vis spectroscopy: suitable

UniProt accession no.

P04985

storage temp.

2-8°C

Quality Level

100

Gene Information

cow ... ELN(280781)

General description

Water-soluble powder prepared by method of Partrige, et al.

Application

Elastin is a structural protein which has been used in studies of chronic obstructive pulmonary disease (COPD). It may be used to investigate why there is a lack of repair for these proteins in patients with COPD.
Highly stable and hemocompatible protein now finding use in construction of biomaterials as a result of several strategies for its solubilization.
Suitable for determination of elastolytic activity as described by Keller and Mandi.

Biochem/physiol Actions

Protein responsible for the elasticity of many tissues. It is especially important in blood vessels, where it comprises about 50% of the dry tissue weight.

Disclaimer

Forms coacervate at pH 5.0 and 37 °C

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

监管及禁止进口产品
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Certificates of Analysis (COA)

Lot/Batch Number
MKDB0171
MKCX8231
MKCV7192
MKCV6983
MKCS9350

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Felix Cleemann et al.
Analytical chemistry, 80(11), 4170-4174 (2008-04-25)
A novel fluorescence polarization assay based on the natural fluorophore epicocconone has been developed. This assay allows the rapid and accurate determination of enzyme kinetic parameters as well as inhibition constants through the measurement of fluorescence anisotropy on the actual
Heath B Henninger et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 31(8), 1226-1233 (2013-04-05)
Elastin is a structural protein that provides resilience to biological tissues. We examined the contributions of elastin to the quasi-static tensile response of porcine medial collateral ligament through targeted disruption of the elastin network with pancreatic elastase. Elastase concentration and
Wei Li et al.
Arteriosclerosis, thrombosis, and vascular biology, 33(5), 1028-1035 (2013-03-16)
Patients with elastin deficiency attributable to gene mutation (supravalvular aortic stenosis) or chromosomal microdeletion (Williams syndrome) are characterized by obstructive arteriopathy resulting from excessive smooth muscle cell (SMC) proliferation, mural expansion, and inadequate vessel size. We investigated whether rapamycin, an
J Tong et al.
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 45(4), 364-372 (2013-02-12)
The main purpose of the present study is the investigation of gender differences in the biomechanical properties, thrombus age, mass fraction and key clinical factors of abdominal aortic aneurysms (AAAs). A total of 90 AAA samples (78 males and 12
Wolfgang G Mouton et al.
Swiss medical weekly, 143, w13755-w13755 (2013-02-28)
The ultrastructure of venous valves and walls in chronic venous disease was investigated. Consecutive patients were categorised into one of three groups (group A: patients with C1 venous disease in accordance with CEAP (Clinical severity, Etiology, Anatomy, Pathophysiology); group B:
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