Key Documents

View All Documentation

E6657

Eplerenone

Name: Eplerenone
Brand: SIGMA

≥98% (HPLC), aldosterone blocker, powder

Synonym(s):

9,11alpha-Epoxy-17-hydroxy-3-oxo-17alpha-pregn-4-ene-7alpha,21-dicarboxylic acid, gamma-lactone, methyl ester, Cgp 30083, Eplerenone [USAN], Epoxymexrenone, HSDB 7522, Inspra, Pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-17-hydroxy-3-oxo-, gamma-lactone, methyl ester, (7alpha,11alpha,17alpha)-, SC-66110

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):

C₂₄H₃₀O₆

CAS Number:

107724-20-9

Molecular Weight:

414.49

MDL number:

MFCD05662207

UNSPSC Code:

51111800

PubChem Substance ID:

329798999

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Product Name

Eplerenone, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed), H₂O: insoluble

storage temp.

2-8°C

SMILES string

O1[C@]32[C@H]1C[C@@]4([C@@]6(OC(=O)CC6)CC[C@H]4[C@@H]3[C@@H](CC5=CC(=O)CC[C@@]52C)C(=O)OC)C

InChI

1S/C24H30O6/c1-21-7-4-14(25)10-13(21)11-15(20(27)28-3)19-16-5-8-23(9-6-18(26)30-23)22(16,2)12-17-24(19,21)29-17/h10,15-17,19H,4-9,11-12H2,1-3H3/t15-,16+,17-,19+,21+,22+,23-,24-/m1/s1

InChI key

JUKPWJGBANNWMW-VWBFHTRKSA-N

Gene Information

human ... NR3C2(4306)

Looking for similar products? Visit Product Comparison Guide

Related Categories

Bioactive Small Molecules

General description

Eplerenone is an aldosterone blocker, which particularly blocks mineralocorticoid receptor. It reduces cardiovascular risk in patients following acute myocardial infarction. Eplerenone is used for treating hypertension and central serous retinopathy. It exhibits potassium sparing diuretic effect.

Application

Eplerenone has been used in quantitative real time (RT-qPCR) or western blotting assays.

Biochem/physiol Actions

Eplerenone is an aldosterone antagonist more specific for the mineralocorticoid receptor than spironolactone (S3378), having lower affinity for progesterone, androgen, and glucocorticoid receptors.

Eplerenone is an aldosterone antagonist.

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

新产品

This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

The memory-facilitating effects of the competitive NMDA-receptor antagonist CGP 37849 are steroid-sensitive, whereas its memory-impairing effects are not.

C Mondadori et al.

Psychopharmacology, 124(4), 380-383 (1996-04-01)

The retention performance of mice in a passive-avoidance task was facilitated by low doses (0.3 mg/kg) of the competitive NMDA-receptor blocker CGP 37849, but impaired by high doses (30 mg/kg). The facilitatory effect was selectively suppressed by elevation of the

Eplerenone, a selective aldosterone blocker, in mild-to-moderate hypertension

Weinberger MH, et al.

American Journal of Hypertension, 15(8), 709-716 (2002)

Antialdosterones: incidence and prevention of sexual side effects.

M de Gasparo et al.

Journal of steroid biochemistry, 32(1B), 223-227 (1989-01-01)

The use of spironolactone in the treatment of hypertension has been limited by the occurrence of sexual side effects, mainly menstrual disturbances in women and gynaecomastia in men. In order to minimize this limitation on the use of an effective

Oral eplerenone for treatment of chronic central serous chorioretinopathy: a case series

Sal DA, et al.

Ophthalmic Surgery, Lasers & Imaging Retina, 46(4), 439-444 (2015)

Eplerenone survival benefits in heart failure patients post-myocardial infarction are independent from its diuretic and potassium-sparing effects: insights from an EPHESUS (Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study) substudy

Rossignol P, et al.

Journal of the American College of Cardiology, 58(19), 1958-1966 (2011)

View All Related Papers

Global Trade Item Number

SKU	GTIN
E6657-10MG	04061833218501
E6657-50MG	04061833218518

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service