Big Endothelin 39 rat

Name: Big Endothelin 39 rat
Brand: SIGMA

≥97% (HPLC)

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About This Item

Empirical Formula (Hill Notation):

C₁₉₂H₂₉₂N₅₀O₅₈S₅

CAS Number:

135842-15-8

Molecular Weight:

4389.00

UNSPSC Code:

12352202

NACRES:

NA.32

MDL number:

MFCD00151519

Assay:

≥97% (HPLC)

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Properties

Quality Segment

200

assay

≥97% (HPLC)

UniProt accession no.

P22388

storage temp.

−20°C

Gene Information

rat ... Edn1(24323)

Description

General description

Big endothelin-1 is a 39 amino acid peptide, which is synthesized and secreted by vascular smooth muscle and endothelium cells. It is produced as an inactive enzyme, and is cleaved and activated by serine and aspartic proteases and metalloproteinases. Activated form is called ET-1, which is a potent vasoconstrictor. ET-1 is also produced by the action of endothelin converting enzyme (ECE) on big-ET-1. In guinea pigs, big-ET-1 causes the release of prostanoids and thromboxanes.

Application

Big Endothelin 39 rat has been used for charting of a standard curve in the study of the role of ET-1 in ventricular dilatation.

Biochem/physiol Actions

Precursor of Endothelin-1; vasoconstrictor activity appears to be due to its conversion to endothelin 1 by endothelin converting enzyme in the tissue.