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E7277

Elastin, soluble from human lung

lyophilized powder

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About This Item

CAS Number:
9007-58-3
NACRES:
NA.61
UNSPSC Code:
12352202
EC Number:
232-701-4
MDL number:
MFCD02687373
Form:
lyophilized powder
Biological source:
human lung

Key Documents

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InChI key

DPUYCSDGMSDKKV-MKBYFEBXSA-N

InChI

1S/C27H48N6O6/c1-9-17(6)23(32-24(36)19(13-15(2)3)30-18(7)34)26(38)29-14-21(35)31-22(16(4)5)27(39)33-12-10-11-20(33)25(37)28-8/h15-17,19-20,22-23H,9-14H2,1-8H3,(H,28,37)(H,29,38)(H,30,34)(H,31,35)(H,32,36)/t17-,19-,20-,22-,23-/m0/s1

biological source

human lung

form

lyophilized powder

impurities

salt, free

solubility

H2O: >10 mg/mL (more soluble at pH>7)

UniProt accession no.

P15502

storage temp.

2-8°C

Quality Level

200

Gene Information

human ... ELN(2006)

Application

Elastin is a structural protein which has been used in studies of chronic obstructive pulmonary disease (COPD). It may be used to investigate why there is a lack of repair for these proteins in patients with COPD.

Preparation Note

Prepared from E7152 using the method of Partrige, et al.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

高风险级别生物产品--人源产品
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Certificates of Analysis (COA)

Lot/Batch Number
SLCG0003
SLBW8534
SLBW2158
SLBQ4758V
SLBJ3770V

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The chemistry of connective tissues. 2. Soluble proteins derived from partial hydrolysis of elastin.
S M PARTRIDGE et al.
The Biochemical journal, 61(1), 11-21 (1955-09-01)
Wei Li et al.
Arteriosclerosis, thrombosis, and vascular biology, 33(5), 1028-1035 (2013-03-16)
Patients with elastin deficiency attributable to gene mutation (supravalvular aortic stenosis) or chromosomal microdeletion (Williams syndrome) are characterized by obstructive arteriopathy resulting from excessive smooth muscle cell (SMC) proliferation, mural expansion, and inadequate vessel size. We investigated whether rapamycin, an
Jae-Yol Lim et al.
PloS one, 8(1), e54256-e54256 (2013-02-02)
Vocal fold (VF) scarring remains a therapeutic challenge. Granulocyte-macrophage colony-stimulating factor (GM-CSF) facilitates epithelial wound healing, and recently, growth factor therapy has been applied to promote tissue repair. This study was undertaken to investigate the effect of GM-CSF on VF
Wolfgang G Mouton et al.
Swiss medical weekly, 143, w13755-w13755 (2013-02-28)
The ultrastructure of venous valves and walls in chronic venous disease was investigated. Consecutive patients were categorised into one of three groups (group A: patients with C1 venous disease in accordance with CEAP (Clinical severity, Etiology, Anatomy, Pathophysiology); group B:
Chris A Bashur et al.
Stem cells translational medicine, 2(6), 401-408 (2013-05-17)
Abdominal aortic aneurysms (AAAs) are potentially fatal conditions that are characterized by decreased flexibility of the aortic wall due to proteolytic loss of the structural matrix. This leads to their gradual weakening and ultimate rupture. Drug-based inhibition of proteolytic enzymes
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