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E7278

Anti-S1P2, C-Terminal antibody produced in rabbit

~1 mg/mL, fractionated antiserum, buffered aqueous solution

Synonym(s):

Anti-EDG-5, Anti-Endothelial Cell Differentiation Gene 5

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD02686109
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
3
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biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

fractionated antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~42 kDa by SDS-PAGE

species reactivity

human

concentration

~1 mg/mL

technique(s)

western blot: suitable

UniProt accession no.

O95136

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... S1PR2(9294)

Immunogen

synthetic peptide (approximately 2.5 kDa, native) derived from the C-terminal region of the EDG-5/S1P2 receptor.

Application

Anti-S1P2, C-Terminal antibody produced in rabbit is suitable for western blotting.

Biochem/physiol Actions

Sphingosine-1-phosphate receptor 2 (S1PR2 or S1P2) is a human gene encodeing a G protein-coupled receptor. It binds the lipid signaling molecule sphingosine 1-phosphate (S1P) and regulates vascular permeability along with S1P1. Activation of S1P2R in endothelial cells increases vascular permeability. It is a bioactive lysophospholipid capable of inducing a wide spectrum of biological responses. S1P acts as an intercellular mediator by interacting with the endothelial differentiation gene (EDG)/S1P family of G protein-coupled receptors. S1P2 receptor is involved in S1P-induced platelet aggregation and Rho kinase activation. Type 2 diabetes patient responds to S1P.

Physical form

Supplied in phosphate buffered saline, pH 7.3, containing 0.08% sodium azide.

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Storage Class

10 - Combustible liquids

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