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E7280

Elafin

Name: Elafin
Brand: SIGMA

recombinant, expressed in Saccharomyces cerevisiae, powder, >90% (by MS, HPLC and SDS-PAGE),

Synonym(s):

Elastase-specific inhibitor, skin-derived antileukoprotease

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About This Item

UNSPSC Code:

12352202

NACRES:

NA.77

MDL number:

MFCD00146824

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Product Name

Elafin human, >90% (by MS, HPLC and SDS-PAGE), recombinant, expressed in Saccharomyces cerevisiae

recombinant

expressed in Saccharomyces cerevisiae

Quality Level

200

assay

>90% (by MS, HPLC and SDS-PAGE)

form

powder

potency

1.7 x 10-10 M K_i (human leukocyte elastase), 4.2 x 10-10 M K_i (human proteinase 3)

mol wt

~6 kDa

UniProt accession no.

P19957

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

enzyme | inhibits

shipped in

ambient

storage temp.

−20°C

Gene Information

human ... PI3(5266)

General description

Chemical structure: peptide

Biochem/physiol Actions

Exhibits co-existent antimicrobial and antiproteolytic activities.1 Inhibits WAP-type four-disulfide core (WFDC) domain containing elastases. Antimicrobial spectrum: Gram-positive and Gram-negative bacteria.

Inhibitor of human leukocyte elastase and proteinase 3, originally isolated from the skin of patients with psoriasis. May protect against certain autoimmune tissue damage.

Inhibitor of human leukocyte elastase and proteinase 3, originally isolated from the skin of patients with psoriasis. May protect against certain autoimmune tissue damage. An elastase inhibitor which is an active fragment of elafin, as well as elafin itself, can also be found in bronchial carcinoma secretions.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

常规特殊物品

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Certificates of Analysis (COA)

Lot/Batch Number

0000519386

0000269791

SLCN7898

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Quantitative analysis of protease recognition by inhibitors in plasma using microscale thermophoresis.

T Dau et al.

Scientific reports, 6, 35413-35413 (2016-10-16)

High abundance proteins like protease inhibitors of plasma display a multitude of interactions in natural environments. Quantitative analysis of such interactions in vivo is essential to study diseases, but have not been forthcoming, as most methods cannot be directly applied

Human Neutrophil Elastase Proteolytic Activity in Ulcerative Colitis Favors the Loss of Function of Therapeutic Monoclonal Antibodies.

Renata Curciarello et al.

Journal of inflammation research, 13, 233-243 (2020-06-18)

Proteases play an essential role in the pathophysiology of inflammatory bowel disease (IBD), contributing to the intestinal mucosal lesions through the degradation of the extracellular matrix and alteration of the barrier function. Ulcerative colitis (UC) is characterized by an extensive

Neutrophil elastase triggers the development of autoimmune diabetes by exacerbating innate immune responses in pancreatic islets of non-obese diabetic mice.

Lingling Shu et al.

Clinical science (London, England : 1979), 134(13), 1679-1696 (2020-07-08)

Type 1 diabetes is an autoimmune disease resulted from self-destruction of insulin-producing pancreatic β cells. However, the pathological pathways that trigger the autoimmune destruction remain poorly understood. Clinical studies have demonstrated close associations of neutrophils and neutrophil elastase (NE) with

Human rElafin Inhibits HIV-1 Replication in Its Natural Target Cells.

Viraj J Jasinghe et al.

BioResearch open access, 2(2), 128-137 (2013-04-18)

Trappin-2/elafin is a novel innate immune factor that belongs to the serine protease inhibitor family and has known antibacterial, antifungal, and antiviral properties. In this study, we further investigated the anti-HIV activity of elafin using different cellular models and both

Elafin inhibits obesity, hyperglycemia, and liver steatosis in high-fat diet-treated male mice.

Jiani Wang et al.

Scientific reports, 10(1), 12785-12785 (2020-08-01)

Elafin is an antimicrobial and anti-inflammatory protein. We hypothesize that elafin expression correlates with diabetes. Among non-diabetic and prediabetic groups, men have significantly higher serum elafin levels than women. Men with type 2 diabetes mellitus (T2DM) have significantly lower serum

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Elastase Function and Importance

Elastase application index for understanding leukocyte elastase, a 29KDa serine endoprotease.

Global Trade Item Number

SKU	GTIN
E7280-100UG	04061833605035

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