E7280
Elafin
recombinant, expressed in Saccharomyces cerevisiae, powder, >90% (by MS, HPLC and SDS-PAGE),
Synonym(s):
Elastase-specific inhibitor, skin-derived antileukoprotease
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About This Item
Product Name
Elafin human, >90% (by MS, HPLC and SDS-PAGE), recombinant, expressed in Saccharomyces cerevisiae
recombinant
expressed in Saccharomyces cerevisiae
Quality Segment
assay
>90% (by MS, HPLC and SDS-PAGE)
form
powder
potency
1.7 x 10-10 M Ki (human leukocyte elastase), 4.2 x 10-10 M Ki (human proteinase 3)
mol wt
~6 kDa
UniProt accession no.
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
enzyme | inhibits
shipped in
ambient
storage temp.
−20°C
Gene Information
human ... PI3(5266)
General description
Chemical structure: peptide
Biochem/physiol Actions
Exhibits co-existent antimicrobial and antiproteolytic activities.1 Inhibits WAP-type four-disulfide core (WFDC) domain containing elastases. Antimicrobial spectrum: Gram-positive and Gram-negative bacteria.
Inhibitor of human leukocyte elastase and proteinase 3, originally isolated from the skin of patients with psoriasis. May protect against certain autoimmune tissue damage.
Inhibitor of human leukocyte elastase and proteinase 3, originally isolated from the skin of patients with psoriasis. May protect against certain autoimmune tissue damage. An elastase inhibitor which is an active fragment of elafin, as well as elafin itself, can also be found in bronchial carcinoma secretions.
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
Eyeshields, Gloves, type N95 (US)
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