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Merck
CN

E7906

Esomeprazole magnesium hydrate

≥98% (HPLC), proton pump inhibitor, powder

Synonym(s):

(S)-Omeprazole magnesium hydrate, (T-4)-Bis[6-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl-κO]-1H-benzimidazolato-κN3]-Magnesium hydrate, Nexium hydrate

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About This Item

Empirical Formula (Hill Notation):
C34H36MgN6O6S2 · xH2O
CAS Number:
668985-31-7
Molecular Weight:
713.12 (anhydrous basis)
MDL number:
MFCD11226784
UNSPSC Code:
12352200
PubChem Substance ID:
329799074
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

Key Documents

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Product Name

Esomeprazole magnesium hydrate, ≥98% (HPLC)

SMILES string

O.COc1ccc2n([Mg]n3c(nc4cc(OC)ccc34)S(=O)Cc5ncc(C)c(OC)c5C)c(nc2c1)S(=O)Cc6ncc(C)c(OC)c6C

InChI

1S/2C17H18N3O3S.Mg.H2O/c2*1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17;;/h2*5-8H,9H2,1-4H3;;1H2/q2*-1;+2;/t2*24-;;/m00../s1

InChI key

LGRFYKXKCZKDLS-DIYDTZFBSA-N

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -128 to -146°, c = 0.5 in methanol

color

white to off-white

solubility

DMSO: ≥5 mg/mL

originator

AstraZeneca

storage temp.

2-8°C

Quality Level

100

Related Categories

Application

Esomeprazole magnesium hydrate has been used to induce intracellular acidification in an ATP12A-independent manner.

Biochem/physiol Actions

Esomeprazole magnesium dihydrate is a leading proton pump inhibitor.

Features and Benefits

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

General description

Esomeprazole is the (S)-isomer of omeprazole. It blocks the H+/K+-ATPase enzyme and lowers the release of hydrochloric acid by gastric parietal cells. Esomeprazole is used for treating gastroesophageal reflux disease (GERD).

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000474958
0000474957
0000474958
0000474957
0000413592

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Yukiko Nakagawa et al.
Biological & pharmaceutical bulletin, 43(4), 682-687 (2020-04-03)
We previously showed that adhesive aggregates were formed when levofloxacin hydrate tablets and lansoprazole orally disintegrating (OD) tablets were suspended in water in the clinical context. In this study, we have clarified the factors causing aggregate formation, focusing on the
Esomeprazole
Scott LJ, et al.
Drugs, 62(10), 1503-1538 (2002)
A review of esomeprazole in the treatment of gastroesophageal reflux disease (GERD)
Kalaitzakis E and Bjornsson E
Therapeutics and Clinical Risk Management, 3(4), 653-653 (2007)
Mitsuhiro Nishihara
European journal of drug metabolism and pharmacokinetics, 44(5), 713-717 (2019-04-18)
A recent report indicated that the pharmacodynamic interaction between clopidogrel and vonoprazan leading to attenuation of the anti-platelet effect of clopidogrel was unlikely to be caused by the inhibition of cytochrome P450 (CYP) 2B6, CYP2C19, or CYP3A4/5 by vonoprazan, based
Susan M Watanabe et al.
Scientific reports, 10(1), 4003-4003 (2020-03-07)
Two proton pump inhibitors, tenatoprazole and esomeprazole, were previously shown to inhibit HIV-1 egress by blocking the interaction between Tsg101, a member of the ESCRT-I complex, and ubiquitin. Here, we deepen our understanding of prazole budding inhibition by studying a
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