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E8280

Exo 1

Name: Exo 1
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

2-(4-Fluorobenzoylamino)benzoic acid methyl ester, 2-(4-Fluorobenzoylamino)methylbenzoate

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About This Item

Empirical Formula (Hill Notation):

C₁₅H₁₂NFO₃

CAS Number:

75541-83-2

Molecular Weight:

273.26

NACRES:

NA.77

PubChem Substance ID:

24724477

UNSPSC Code:

12352203

MDL number:

MFCD00028104

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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Properties

Quality Level

100

assay

≥98% (HPLC)

form

solid

solubility

DMSO: soluble 19 mg/mL

SMILES string

COC(=O)c1ccccc1NC(=O)c2ccc(F)cc2

InChI

1S/C15H12FNO3/c1-20-15(19)12-4-2-3-5-13(12)17-14(18)10-6-8-11(16)9-7-10/h2-9H,1H3,(H,17,18)

InChI key

KIAPWMKFHIKQOZ-UHFFFAOYSA-N

Description

Application

Exo 1 has been used as a component of the BRB80 buffer to study coat protein 1 (COPI)-mediated membrane trafficking. It has also been used as a Golgi inhibitor to study its effects on the long interspersed nuclear element-1 (L1) retrotransposition.

Biochem/physiol Actions

Exo 1 is a cell-permeable methylanthranilate analog that promotes the release of adenosine diphosphate (ADP)-ribosylation factor (ARF) 1 from Golgi membranes. It also inhibits the membrane trafficking between the endoplasmic reticulum (ER) and the Golgi bodies.

Reversible inhibitor of exocytosis; Golgi ARF 1 (ADP-Ribosylation Factor) GTPase activator.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number

0000152224

0000132629

0000132630

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Characterization of class I and II ADP-ribosylation factors (Arfs) in live cells: GDP-bound class II Arfs associate with the ER-Golgi intermediate compartment independently of GBF1.

Justin Chun et al.

Molecular biology of the cell, 19(8), 3488-3500 (2008-06-06)

Despite extensive work on ADP-ribosylation factor (Arf) 1 at the Golgi complex, the functions of Arf2-5 in the secretory pathway, or for that of any Arf at the ER-Golgi intermediate compartment (ERGIC) remain uncharacterized. Here, we examined the recruitment of

The potential for a CRISPR gene drive to eradicate or suppress globally invasive social wasps.

Philip J Lester et al.

Scientific reports, 10(1), 12398-12398 (2020-07-28)

CRISPR gene drives have potential for widespread and cost-efficient pest control, but are highly controversial. We examined a potential gene drive targeting spermatogenesis to control the invasive common wasp (Vespula vulgaris) in New Zealand. Vespula wasps are haplodiploid. Their life

Time-lapse observation of chromosomes, cytoskeletons and cell organelles during male meiotic divisions in Drosophila

Tanabe K, et al.

Bio-protocol, 7, e2225-e2225 (2017)

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Global Trade Item Number

SKU	GTIN
E8280-5MG	04061833476420
E8280-25MG	04061833270875