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E8750

α-Estradiol

Name: &#945;-Estradiol
Brand: SIGMA

synthetic (organic), ≥98% (TLC), Endogenous estrogen receptor agonist, powder

Synonym(s):

1,3,5(10)-Estratriene-3,17α-diol, 3,17α-Dihydroxy-1,3,5(10)-estratriene, Epiestradiol

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₂₄O₂

CAS Number:

57-91-0

Molecular Weight:

272.38

NACRES:

NA.77

PubChem Substance ID:

24894682

UNSPSC Code:

12352200

EC Number:

200-354-8

MDL number:

MFCD00064144

Assay:

≥98% (TLC)

Form:

powder

Quality level:

200

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Product Name

α-Estradiol, powder, ≥98% (TLC)

biological source

synthetic (organic)

Quality Level

200

assay

≥98% (TLC)

form

powder

color

white to slight yellow

solubility

ethanol: 50 mg/mL, clear, colorless

shipped in

ambient

storage temp.

room temp

SMILES string

[H][C@]12CC[C@]3(C)[C@H](O)CC[C@@]3([H])[C@]1([H])CCc4cc(O)ccc24

InChI

1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17-,18+/m1/s1

InChI key

VOXZDWNPVJITMN-SFFUCWETSA-N

Gene Information

human ... ESR1(2099), ESR2(2100)
rat ... Ar(24208)

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Related Categories

Bioactive Small Molecules

Biochem/physiol Actions

Estradiol (known as alpha Estradiol or 17 alpha Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture.17-estradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer′s disease and ischemic stroke.

pictograms

GHS08,GHS09

signalword

Danger

hcodes

H341,H351,H360F,H362,H410

pcodes

P202 - P260 - P263 - P264 - P273 - P308 + P313

Hazard Classifications

Aquatic Chronic 1 - Carc. 2 - Lact. - Muta. 2 - Repr. 1A

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

涉药品监管产品

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Certificates of Analysis (COA)

Lot/Batch Number

0000518182

0000518180

0000518181

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Testosterone dependent androgen receptor stabilization and activation of cell proliferation in primary human myometrial microvascular endothelial cells.

Wolf Dietrich et al.

Fertility and sterility, 95(4), 1247-1255 (2010-12-07)

To clarify, whether uterine endothelial proliferation could be regulated via an autocrine estrogen producing mechanism or direct actions of testosterone. In vitro study. Tertiary care facility. Human myometrial tissue obtained from 40 women undergoing hysterectomy without further intrauterine pathology. Cell

New Drug Repositioning Candidates for T-ALL Identified Via Human/Murine Gene Signature Comparison.

Raphaël Bonnet et al.

Frontiers in oncology, 10, 557643-557643 (2020-11-27)

T-cell Acute Lymphoblastic Leukemia (T-ALL) is an aggressive subtype of leukemia for which important progress in treatment efficiency have been made in the past decades to reach a cure rate of 75%-80% nowadays. It is nevertheless mandatory to find new

Estrogen responsiveness of the TFIID subunit TAF4B in the normal mouse ovary and in ovarian tumors.

Jennifer R Wardell et al.

Biology of reproduction, 89(5), 116-116 (2013-09-27)

Estrogen signaling in the ovary is a fundamental component of normal ovarian function, and evidence also indicates that excessive estrogen is a risk factor for ovarian cancer. We have previously demonstrated that the gonadally enriched TFIID subunit TAF4B, a paralog

The effect of steroids on the in vitro migration of washed human spermatozoa in modified Tyrode's solution or in fasting human blood serum.

C Y Cheng et al.

Fertility and sterility, 32(5), 566-570 (1979-11-01)

In modified Tyrode's solution, 17 beta-estradiol at concentrations between 0.1 microgram/ml and 320 nmoles/ml was effective in increasing human spermatozoal forward migration. 17 alpha-Estradiol, although structurally similar to 17 beta-estradiol, had no effect on human spermatozoal motility. DL-Norgestrel at concentrations

3-Hydroxyglutarate excretion is increased in ketotic patients: implications for glutaryl-CoA dehydrogenase deficiency testing.

J Pitt et al.

Journal of inherited metabolic disease, 25(2), 83-88 (2002-07-18)

Three patients with ketosis had increased excretion of 3-hydroxyglutarate (21.8-37.9 micromol/mmol creatinine; controls 2.3 +/- 1.6), an indicator of glutaryl-CoA dehydrogenase deficiency (GDHD), which normalized when the patients were nonketotic. Clinical assessment of all three patients and enzyme studies in

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Global Trade Item Number

SKU	GTIN
E8750-1G	04061833608845
E8750-100MG	04061833608838
E8750-500MG	04061832850078

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