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Merck
CN

EHU024351

MISSION® esiRNA

targeting human SLC25A11

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About This Item

NACRES:
NA.51
UNSPSC Code:
41105324

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description

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product line

MISSION®

form

lyophilized powder

esiRNA cDNA target sequence

GAACATGCGGATGATTGATGGGAAGCCGGAATACAAGAACGGGCTGGACGTGCTGTTCAAAGTTGTCCGCTACGAGGGCTTCTTCAGCCTGTGGAAGGGCTTCACGCCGTACTATGCCCGCCTGGGCCCCCACACCGTCCTCACCTTCATCTTCTTGGAGCAGATGAACAAGGCCTACAAGCGTCTCTTCCTCAGTGGCTGAAGCGGCCGGGGGCTCCCACTCGCCTGCTGCGCCTATAGCCACTGCGCCCTGGGGGCCTGGGCTCTGCTGCCCTGGACCCCTCTATTTATTTCCCTTCCACAGTGTGGTTTCTTCCTCTGCGGTAAAGGACTTGGTCTGTTCTACCCCCTGCTCCAGCTTGCCCTGCTCGTCCTGATCCTGTGATTTCTCTGTCCTTGGCTATTCTTGCAGGGAGCTGG

Ensembl | human accession no.

ENSG00000108528

NCBI accession no.

NM_003562

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Related Categories

General description

MISSION® esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

Legal Information

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

12 - Non Combustible Liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Anna Baulies et al.
Redox biology, 14, 164-177 (2017-09-25)
Cancer cells exhibit mitochondrial cholesterol (mt-cholesterol) accumulation, which contributes to cell death resistance by antagonizing mitochondrial outer membrane (MOM) permeabilization. Hepatocellular mt-cholesterol loading, however, promotes steatohepatitis, an advanced stage of chronic liver disease that precedes hepatocellular carcinoma (HCC), by depleting
Mo Wang et al.
Investigative ophthalmology & visual science, 60(2), 500-516 (2019-02-02)
To characterize two mitochondrial membrane transporters 2-oxoglutarate (OGC) and dicarboxylate (DIC) in human RPE (hRPE) and to elucidate their role in the regulation of mitochondrial glutathione (mGSH) uptake and cell death in oxidative stress. The localization of OGC and DIC

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