EHU103381
MISSION® esiRNA
targeting human LGR4
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About This Item
NACRES:
NA.51
UNSPSC Code:
41105324
description
Powered by Eupheria Biotech
Quality Level
product line
MISSION®
form
lyophilized powder
esiRNA cDNA target sequence
TCAGGCTATTAAAGCCCTTCCTAGCCTTAAAGAGCTAGGATTTCATAGTAATTCTATTTCTGTTATCCCTGATGGAGCATTTGATGGTAATCCACTCTTAAGAACTATACATTTGTATGATAATCCTCTGTCTTTTGTGGGGAACTCAGCATTTCACAATTTATCTGATCTTCATTCCCTAGTCATTCGTGGTGCAAGCATGGTGCAGCAGTTCCCCAATCTTACAGGAACTGTCCACCTGGAAAGTCTGACTTTGACAGGTACAAAGATAAGCAGCATACCTAATAATTTGTGTCAAGAACAAAAGATGCTTAGGACTTTGGACTTGTCTTACAATAATATAAGAGACCTTCCAAGTTTTAATGGTTGCCATGCTCTGGAAGAAATTTCTTTACAGCGTAATCAAATCTACCAAATAAAGGAAGGCACCTTTCAAGG
Ensembl | human accession no.
NCBI accession no.
shipped in
ambient
storage temp.
−20°C
Gene Information
human ... LGR4(55366)
General description
MISSION esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.
For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.
For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.
Legal Information
MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Liping Zhang et al.
EBioMedicine, 44, 275-288 (2019-05-18)
R-spondins (Rspo) and leucine-rich repeat-containing G-protein-coupled receptors (LGR) play important roles in development, stem cells survival, and tumorigenicity by activating Wnt signaling pathway. Whether R-spondins-LGR signaling affects the progression of squamous cell carcinoma (SCC) remain unknown. This study aims to
Basit Salik et al.
Cancer cell, 38(2), 263-278 (2020-06-20)
Signals driving aberrant self-renewal in the heterogeneous leukemia stem cell (LSC) pool determine aggressiveness of acute myeloid leukemia (AML). We report that a positive modulator of canonical WNT signaling pathway, RSPO-LGR4, upregulates key self-renewal genes and is essential for LSC
Global Trade Item Number
| SKU | GTIN |
|---|---|
| EHU103381-20UG | 04061828601165 |
| EHU103381-50UG | 04061828367979 |