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EHU160361

MISSION® esiRNA

targeting human TIMM22

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NACRES:
NA.51
UNSPSC Code:
41105324
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description

Powered by Eupheria Biotech

Quality Level

100

product line

MISSION®

form

lyophilized powder

esiRNA cDNA target sequence

TGGAGGTTTTGCTGCTTTCTCTGCTGCGATTGATTATTACCTCCGGTGAGAGTAATTGCCTGCAGGGAAGGATGATGCCAGCCCCGGATCCGGGCTGCTCTCTGGAGGACAGTTTCTGTACCACACCAGGGCCTTGCTTCAGGGCCTGAAGACATTCATTTTCCCTCATGTCGTTGGTATTCTGAGGGAGCTGCCTGGCTTCTCTGCCTCCAGCCTTTGGGGTAGCCACACTTTGCTGCTCCTGGACTCCAGCCAGCCTTCACAGAGGACGTCCCGTGCCAGATTCTCTCACAGCAGATCGGGAGACAGGATGTTGACATATAGGAATTCAGCTCCACAAAGCTTCAGGCCTGACCACAGCTGGCCCTCTAGGTTGTTTGGTGTTGTGGGCACAGAGGTGACAGTGTCTCTGCAGGCACTCAGGAAGCTGTTCTACCTTGGAACTCCATGCAAC

Ensembl | human accession no.

ENSG00000177370

NCBI accession no.

NM_013337

shipped in

ambient

storage temp.

−20°C

Gene Information

human ... TIMM22(29928)

General description

MISSION esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

Legal Information

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Ridhima Gomkale et al.
Current biology : CB, 30(6), 1119-1127 (2020-03-07)
In mitochondria, the carrier translocase (TIM22 complex) facilitates membrane insertion of multi-spanning proteins with internal targeting signals into the inner membrane [1-3]. Tom70, a subunit of TOM complex, represents the major receptor for these precursors [2, 4-6]. After transport across
Sylvie Callegari et al.
FEBS letters, 590(23), 4147-4158 (2016-10-28)
Hydrophobic inner mitochondrial membrane proteins with internal targeting signals, such as the metabolite carriers, use the carrier translocase (TIM22 complex) for transport into the inner membrane. Defects in this transport pathway have been associated with neurodegenerative disorders. While the TIM22

Global Trade Item Number

SKUGTIN
EHU160361-20UG04061831367874
EHU160361-50UG04061828420827