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EMU051841

MISSION® esiRNA

targeting mouse Grem1

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About This Item

NACRES:
NA.51
UNSPSC Code:
41105324
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description

Powered by Eupheria Biotech

Quality Level

100

product line

MISSION®

form

lyophilized powder

esiRNA cDNA target sequence

TTCTGCAAGCCCAAGAAGTTCACCACCATGATGGTCACACTCAACTGTCCTGAGCTACAGCCACCCACCAAGAAGAAAAGGGTCACACGCGTGAAGCAGTGCCGTTGCATATCCATCGACTTGGATTAAGTCAAAGCGGGCACATTCAGCCTGTCATAGCCATGCTGAGAGAGCCACACCCAAACCACCCGATTCCTACTTGGCTTAAACCTAGAGGCCAGAAGAACCAGCAGTTGCTTCCTGGCTGGAGGCTGCTTATGCATAGTGTATGCGCATGAGTGTGCATGGGTGCCTGTGGGTGTTTCCAAACACCAGCCGGAAACAGCCTTTGCTAGAAGGCACTTCCTGTTACTCTGCTTCAGATGGTCGGAAATGCCCACACCACTGGACCCAAACATCCACAGGGGCAGGGCTGTAGTTGGCTTTGTCATTGTGTTCCATGTGCCT

Ensembl | mouse accession no.

ENSMUSG00000074934

NCBI accession no.

NM_011824

shipped in

ambient

storage temp.

−20°C

Gene Information

mouse ... GREM1(23892), Grem1(23892)

General description

MISSION® esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

Legal Information

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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GAV

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Na Hui Kim et al.
Biochemical and biophysical research communications, 533(4), 1378-1384 (2020-10-25)
Gremlin-1 (GREM1), one of the antagonists of bone morphogenetic proteins (BMPs), has recently been reported to be overexpressed in a variety of cancers including breast cancer. GREM1 is involved in tumor promotion, but little is known about its role in
Nam Ji Sung et al.
International journal of molecular sciences, 21(23) (2020-12-09)
Gremlin-1 (GREM1), one of the bone morphogenetic protein (BMP) antagonists, can directly bind to BMPs. GREM1 is involved in organogenesis, tissue differentiation, and organ fibrosis. Recently, numerous studies have reported the oncogenic role of GREM1 in cancer. However, the role
Julie R Graham et al.
Journal of cellular biochemistry, 115(9), 1539-1548 (2014-03-19)
Fibrosis is a chronic disease characterized by an excessive deposition of scar tissue in the affected organs. A central mediator of this process is transforming growth factor-β (TGF-β), which stimulates the production of extracellular matrix proteins such as collagens. MicroRNAs

Global Trade Item Number

SKUGTIN
EMU051841-50UG04061828286041
EMU051841-20UG04061828511419