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EMU073461

MISSION® esiRNA

targeting mouse Mkl1

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About This Item

NACRES:
NA.51
UNSPSC Code:
41105324
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description

Powered by Eupheria Biotech

Quality Level

100

product line

MISSION®

form

lyophilized powder

esiRNA cDNA target sequence

GAGCAGAGAAGAAGCCTGGAGCGGGCCAGGACCGAGGACTATTTGAAACGGAAGATCCGTTCCCGGCCCGAGAGAGCAGAGCTGGTCAGGATGCACATTCTGGAAGAGACCTCGGCTGAGCCTTCGCTCCAGGCCAAGCAGCTGAAGCTGAAGAGAGCCAGGCTGGCTGATGACCTCAATGAAAAGATTGCACAGAGGCCTGGCCCCATGGAGCTGGTGGAGAAGAATATCCTGCCTGTGGAGTCCAGCCTGAAGGAGGCTATCATTGTGGGCCAGGTAAATTACCCAAAGGTAGCAGACAGTTCCTCCTTCGACGAGGACAGCAGCGATGCCCTGTCTCCTGAGCAGCCTGCCAGCCATGAGTCCCAGGGTTCAGTGCCATCACCCTTGGAGTCCCGAGTCAGTGATCCACTGCCCAGTGCCACCTCCATATCACC

Ensembl | mouse accession no.

ENSMUSG00000042292

NCBI accession no.

NM_153049

shipped in

ambient

storage temp.

−20°C

Gene Information

mouse ... MKL1(223701), Mkl1(223701)

General description

MISSION® esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

Legal Information

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Xu Shiwen et al.
PloS one, 10(5), e0126015-e0126015 (2015-05-09)
In scleroderma (systemic sclerosis, SSc), persistent activation of myofibroblast leads to severe skin and organ fibrosis resistant to therapy. Increased mechanical stiffness in the involved fibrotic tissues is a hallmark clinical feature and a cause of disabling symptoms. Myocardin Related
Philipp Kircher et al.
Science signaling, 8(402), ra112-ra112 (2015-11-12)
Megakaryoblastic leukemia 1 (MKL1) is a coactivator of serum response factor (SRF) that promotes the expression of genes associated with cell proliferation, motility, adhesion, and differentiation-processes that also involve dynamic cytoskeletal changes in the cell. MKL1 is inactive when bound

Global Trade Item Number

SKUGTIN
EMU073461-50UG04061828306503
EMU073461-20UG04061831348132