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EPI009

Histone Deacetylase (HDAC) Inhibitor Set II

Set includes 7 inhibitors

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352200
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shipped in

wet ice

storage temp.

−20°C

General description

A convenient set of seven individual HDAC (Histone Deacetylase) inhibitors.
  • CI-994
CAS Number: 112522-64-2
Molecular Formula: C15H15N3O2
Molecular Weight: 269.3
  • Panobinostat (LBH589)
CAS Number: 404950-80-7
Molecular Formula: C21H23N3O2
Molecular Weight: 349.43
  • SAHA
CAS Number: 149647-78-9
Molecular Formula: C14H20N2O3
Molecular Weight: 264.3
  • SBHA
CAS Number: 38937-66-5
Molecular Formula: C8H16N2O4
Molecular Weight: 204.22
  • Scriptaid
CAS Number: 287383-59-9
Molecular Formula: C18H18N2O4
Molecular Weight: 326.35
  • Trichostatin A
CAS Number: 58880-19-6
Molecular Formula: C17H22N2O3
Molecular Weight: 302.4
  • Tubacin
CAS Number: 537049-40-4
Molecular Formula: C41H43N3O7S
Molecular Weight: 721.86

Biochem/physiol Actions

  • CI-994 - Cell-permeable. A histone deacetylase (HDAC) inhibitor: Ki values are 0.41, 0.75, >100 and >100 μM for HDAC1, HDAC3, HDAC6 and HDAC8, respectively. Displays significant antitumor activity in vitro and in vivo against a broad spectrum of murine and human tumor models.
  • Panobinostat (LBH589) - Highly potent inhibitor of both histone deacetylase 1 (HDAC1) activity and tumour cell proliferation in vitro. The IC50 values of HDAC isozymes HDAC1-IP Ac-H4, HDAC8, MALunselective, B61HDAC1 and B12HDAC6 are 0.23±0.06, 283±29, 75±4, 47±5 and 89±12 nM, respectively. And to A2780 proliferation, IC50 value is 4.6±1.8 nM.
  • SAHA - Potent, reversible inhibitor of histone deacetylase 1 (HDAC1) and 3 (HDAC3). Induces cell growth arrest at both G1 and G2 phases. Induces apoptosis.
  • SBHA - Competitive histone deacetylase (HDAC) inhibitor that has been shown to inhibit HDAC1 (IC50 = 0.25 μM) and HDAC3 (IC50 = 0.30 μM). SBHA causes cell differentiation, cell cycle arrest, or apoptosis. SBHA also enhances cytotoxicity induced by Oxaliplatin in the colorectal cancer cell lines.
  • Scriptaid - A relatively non-toxic Inhibitor of histone deacetylase (HDAC). Facilitates transcriptional activation (TGF-β/Smad4) in both stable and transient receptor assays in a concentration-dependent manner. At ~2 μg/ml (6-8 μM) concentrations, results in a greater than 100-fold increase in histone acetylation in PANC-1 cells.
  • Trichostatin A - Potent, reversible inhibitor of histone deacetylase. Mediates the activation of O6-methylguanine-DNA methyltransferase (MGMT). May be involved in cell cycle progression of several cell types, induces cell growth arrest at both G1 and G2/M phases. In some cases induces apoptosis.
  • Tubacin - Tubacin (Tubulin acetylation inducer) is a highly potent, selective, reversible, and cell-permeable inhibitor of histone deacetylase 6 (HDAC6, IC50 = 4 nM). Displays 1000-fold more selectivity for HDAC6 over other HDACs. It inhibits α-tubulin deacetylation in mammalian cells. Unlike trichostatin A (TSA), which is a broad spectrum HDAC inhibitor, tubacin is specific for the tubulin deacetylase activity of HDAC6. Tubacin causes increased acetylation of α-tubulin, accumulation of polyubiquitinated proteins, and apoptosis. It does not affect global histone deacetylation, gene-expression profiling, or cell cycle progression mediated α-tubulin deacetylation in mammalian cells.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Dam. 1 - Muta. 2 - Repr. 1A - Skin Irrit. 2 - STOT RE 2 Inhalation

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

188.6 °F - closed cup

flash_point_c

87 °C - closed cup

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