Name: Fusidic acid
Brand: SIGMA

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About This Item

Empirical Formula (Hill Notation):

C₃₁H₄₈O₆

CAS Number:

6990-06-3

Molecular Weight:

516.71

EC Number:

230-256-0

MDL number:

MFCD00865135

UNSPSC Code:

12352106

PubChem Substance ID:

57654174

NACRES:

NA.77

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storage temp.

2-8°C

SMILES string

[H][C@@]12CC[C@@]3(C)[C@@]([H])([C@H](O)C[C@@]4([H])\C([C@H](C[C@]34C)OC(C)=O)=C(/CC\C=C(\C)C)C(O)=O)[C@@]1(C)CC[C@@H](O)[C@H]2C

InChI

1S/C31H48O6/c1-17(2)9-8-10-20(28(35)36)26-22-15-24(34)27-29(5)13-12-23(33)18(3)21(29)11-14-30(27,6)31(22,7)16-25(26)37-19(4)32/h9,18,21-25,27,33-34H,8,10-16H2,1-7H3,(H,35,36)/b26-20-/t18-,21-,22-,23+,24+,25-,27-,29-,30-,31-/m0/s1

InChI key

IECPWNUMDGFDKC-MZJAQBGESA-N

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Application

Fusidic acid has been used:

as a standard in thin-layer chromatography (TLC)-densitometric method
to study its ability to bind to human serum albumin
as an antibiotic in combination with tannic acid to determine minimum inhibitory concentrations (MIC) in methicillin-resistant Staphylococcus aureus (MRSA)

Biochem/physiol Actions

Fusidic acid is a tetracyclic triterpenoid with antibiotic activity against Gram-positive bacteria. It is derived from Fusidium coccineum. It shows its activity against anaerobes, corynebacterial, Nocardia, and Neisseria species. Fusidic acid exhibits therapeutic effects against Staphylococcal infections, skin infections.

Suppresses nitric oxide lysis of pancreatic islet cells. Inhibits protein synthesis in prokaryotes by inhibiting the ribosome-dependent activity of G factor and translocation of peptidyl-tRNA.

Suppresses nitric oxide lysis of pancreatic islet cells; inhibits protein synthesis in prokaryotes.

Pictograms

GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 + P330 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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