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Merck
CN

F0808

Sigma-Aldrich

Frondoside A hydrate

≥96% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C60H95O29S·Na · xH2O
CAS Number:
127367-76-4
Molecular Weight:
1335.43 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
329799669
NACRES:
NA.77

Key Documents

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Assay

≥96% (HPLC)

form

powder

storage condition

desiccated

color

white to off-white

solubility

H2O: ≥10 mg/mL

storage temp.

−20°C

SMILES string

[Na+].COC1C(O)C(CO)OC(OC2C(O)COC(OC3C(C)OC(OC4C(O)C(COC4O[C@H]5CC[C@]6(C)C7CCC89C([C@H](C[C@@]8(C)C7=CCC6C5(C)C)OC(C)=O)[C@](C)(CCCC(C)C)OC9=O)OS([O-])(=O)=O)C(OC%10OCC(O)C(O)C%10O)C3O)C2O)C1O

InChI

1S/C60H96O29S.Na/c1-25(2)12-11-17-59(9)49-32(81-27(4)62)20-58(8)29-13-14-35-56(5,6)36(16-18-57(35,7)28(29)15-19-60(49,58)55(72)88-59)83-53-47(39(67)34(24-79-53)89-90(73,74)75)87-54-48(86-50-40(68)37(65)30(63)22-77-50)41(69)44(26(3)80-54)84-51-42(70)45(31(64)23-78-51)85-52-43(71)46(76-10)38(66)33(21-61)82-52;/h13,25-26,28,30-54,61,63-71H,11-12,14-24H2,1-10H3,(H,73,74,75);/q;+1/p-1/t26?,28?,30?,31?,32-,33?,34?,35-,36-,37?,38?,39?,40?,41?,42?,43?,44?,45?,46?,47?,48?,49+,50?,51?,52?,53?,54?,57+,58-,59-,60?;/m0./s1

InChI key

JVAXTYZSDXFKMH-RYKXRNEYSA-M

Biochem/physiol Actions

Frondoside A is a bioactive triterpenoid saponin from sea cucumber; and an immunostimulant.
Frondoside A is a bioactive triterpenoid saponin from sea cucumber; and an immunostimulant. Frondoside A is an extremely potent inducer of apoptosis, and although it does activate caspaces, it can induce apoptosis in HL-60 cells through a mechanism distinct from extrinsic and intrinsic apoptosis pathways. It potentially valuable for cancers that are resistent to other apoptosis inducers, such as pancreatic cancer.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
110M4718V
0000024193

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