F1642
Flurandrenolide
Synonym(s):
6α-Fluoro-11β,16α,17,21-tetrahydroxypregn-4-ene-3,20-dione 16,17-acetonide, Fludroxycortide
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About This Item
Empirical Formula (Hill Notation):
C24H33FO6
CAS Number:
Molecular Weight:
436.51
UNSPSC Code:
12352200
PubChem Substance ID:
EC Number:
216-196-8
MDL number:
SMILES string
CC1(C)O[C@@H]2CC3C4C[C@H](F)C5=CC(=O)CCC5(C)C4C(O)CC3(C)[C@@]2(O1)C(=O)CO
InChI
1S/C24H33FO6/c1-21(2)30-19-9-14-13-8-16(25)15-7-12(27)5-6-22(15,3)20(13)17(28)10-23(14,4)24(19,31-21)18(29)11-26/h7,13-14,16-17,19-20,26,28H,5-6,8-11H2,1-4H3/t13?,14?,16-,17?,19+,20?,22?,23?,24+/m0/s1
InChI key
POPFMWWJOGLOIF-CCRGDLLISA-N
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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E L Jones et al.
Cutis, 21(6), 881-885 (1978-06-01)
New methods are now available to help select vehicles for topical corticosteroids. In the development of a new cream vehicle for flurandrenolide, the goal was a cream base with optimal solubility for release of the drug, minimal irritation potential, and
H Nakamura et al.
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 76(7), 595-607 (1980-10-01)
Fludroxycortide tape is a thin plastic tape which contains a synthetic glucocorticoid, fludroxycortide of 4 microgram/cm2. fludroxycortide tape with a topical application of 1 cm2 inhibited significantly contact hypersensitivities to oxazolone and picryl chloride in the ear skin of mice
B M Hausen et al.
Dermatosen in Beruf und Umwelt. Occupation and environment, 33(1), 27-28 (1985-01-01)
A 66-year-old female developed increasing eczematous reactions after treatment of her leg ulcer with a corticoid ointment. When patch tested with the constituents she reacted positive to fludroxycortide (flurandrenolone) and cetyl alcohol. Contact allergy to this fluorinated corticosteroid has not