F2177
Follistatin 288 from mouse
>95% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder
Synonym(s):
FS-288
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About This Item
biological source
mouse
Quality Segment
recombinant
expressed in baculovirus infected Sf21 cells
assay
>95% (SDS-PAGE)
form
lyophilized powder
potency
0.04-0.4 mg per mL
mol wt
calculated mol wt ~31 kDa
packaging
pkg of 25 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
mouse ... Fst(14313)
General description
FST (follistatin) is an activin-binding protein, and exists in two isoforms due to alternate splicing, FS288 and FS315. It is a glycoprotein with a single chain, and acts as an activin antagonist. It has a high level of expression in fetal membranes and placenta.
Biochem/physiol Actions
FST (follistatin) binds to and regulates activins, which in turn are TGF (transforming growth factor)-β superfamily members. The expression level of FST and its binding partner activin A is elevated in inflammatory disorders. The activin A-follistatin system plays an essential role in the modulation of glucose and lipid metabolism, which might have an overall effect on fetal growth. In adipose tissue, it facilitates the adipogenic differentiation of progenitor cells.
High affinity activin-binding protein that can act as an activin antagonist.
Physical form
Recombinant Mouse Follistatin 288 is supplied as a approximately 25 μg of protein lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% TFA containing 1.25 mg of bovine serum albumin.
Analysis Note
The biological activity is measured by its ability to neutralize activin-induced erythroid differentiation on K562 cells.
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Instructions
Global Trade Item Number
| SKU | GTIN |
|---|---|
| F2177-25UG | 04061833612804 |