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F2427

Fluprostenol isopropyl ester

Name: Fluprostenol isopropyl ester
Brand: SIGMA

≥98%, ethanol solution

Synonym(s):

(±)-16-(m-Trifluoromethylphenoxy)tetranorprostaglandin F₂, Travoprost

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About This Item

Empirical Formula (Hill Notation):

C₂₆H₃₅F₃O₆

CAS Number:

157283-68-6

Molecular Weight:

500.55

NACRES:

NA.77

PubChem Substance ID:

329799691

UNSPSC Code:

12352200

EC Number:

200-578-6

MDL number:

MFCD03411995

Assay:

≥98%

Form:

ethanol solution

Quality level:

200

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Quality Level

200

assay

≥98%

form

ethanol solution

shipped in

wet ice

storage temp.

−20°C

SMILES string

CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)COc2cccc(c2)C(F)(F)F

InChI

1S/C26H35F3O6/c1-17(2)35-25(33)11-6-4-3-5-10-21-22(24(32)15-23(21)31)13-12-19(30)16-34-20-9-7-8-18(14-20)26(27,28)29/h3,5,7-9,12-14,17,19,21-24,30-32H,4,6,10-11,15-16H2,1-2H3/b5-3-,13-12+/t19-,21-,22-,23+,24-/m1/s1

InChI key

MKPLKVHSHYCHOC-AHTXBMBWSA-N

Gene Information

human ... PTGFR(5737)

Biochem/physiol Actions

Potent FP prostanoid receptor agonist used in animal models for glaucoma.

Disclaimer

Supply conditions do not apply to the regions and states of Brazil: North, Northeast, Mato Grosso do Sul, Mato Grosso, and Rio Grande do Sul.

pictograms

GHS02,GHS07

signalword

Danger

hcodes

H225,H319

pcodes

P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2

Storage Class

3 - Flammable liquids

wgk

WGK 2

flash_point_f

62.6 °F - closed cup

flash_point_c

17 °C - closed cup

Regulatory Information

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Comparison of the toxicity profile of benzalkonium chloride-preserved tafluprost and SofZia-preserved travoprost applied to the ocular surface.

Takashi Kanamoto et al.

Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 31(3), 156-164 (2015-02-25)

To evaluate some clinically important features of benzalkonium chloride (BAK) toxicity by comparing tafluprost with 0.001% BAK and travoprost preserved with SofZia applied to the ocular surface of the eyes with glaucoma. This was a prospective, randomized, observer unmasked, multicenter

Influence of local application of glaucoma medications-travoprost eye drops on patients' tear film function.

Chengpu Zhang

Pakistan journal of pharmaceutical sciences, 28(2 Suppl), 781-784 (2015-03-23)

This study discussed about the influence of local application of glaucoma medications -- travoprost eye drops to patients' tear film function. We selected 24 patients, 45 eyes with primary open-angle glaucoma or intraocular hypertension. All of the patients topically used

IOP-Lowering Effect of ONO-9054, A Novel Dual Agonist of Prostanoid EP3 and FP Receptors, in Monkeys.

Shinsaku Yamane et al.

Investigative ophthalmology & visual science, 56(4), 2547-2552 (2015-03-20)

The purpose of this study was to determine whether a better IOP reduction can be observed in conscious, normotensive monkeys treated with ONO-9054, a novel dual EP3 and FP receptor agonist, compared with prostaglandin F2α analogs. The binding affinities and

Effect of benzalkonium chloride-free travoprost on intraocular pressure and ocular surface symptoms in patients with glaucoma previously on latanoprost: an open-label study.

Joao F Lopes et al.

BMC ophthalmology, 15, 166-166 (2015-11-14)

Prostaglandin analogs reduce intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension; however, these medications may affect the ocular surface and elicit ocular discomfort when preserved with benzalkonium chloride (BAK). This was an open-label, single-arm study conducted in

Safety and Efficacy of Benzalkonium Chloride-optimized Tafluprost in Japanese Glaucoma Patients With Existing Superficial Punctate Keratitis.

Katsuyoshi Suzuki et al.

Journal of glaucoma, 24(6), e145-e150 (2013-11-19)

To evaluate the safety and efficacy of benzalkonium chloride (BAK)-optimized tafluprost (with a BAK concentration reduced from 0.01% to 0.001%) in glaucoma patients with existing superficial punctate keratitis (SPK). A prospective, multicenter, open-label study was designed to compare BAK-optimized tafluprost

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Global Trade Item Number

SKU	GTIN
F2427-1MG	04061838063717

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