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F3771

Fumonisin B₂

Name: Fumonisin B&#8322;
Brand: SIGMA

From Fusarium sp. (Fusarium moniliforme), ≥96% (TLC), Sphingosine N-acyltransferase inhibitor, powder

Synonym(s):

FB₂, Fumonisin B₂

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About This Item

Empirical Formula (Hill Notation):

C₃₄H₅₉NO₁₄

CAS Number:

116355-84-1

Molecular Weight:

705.83

UNSPSC Code:

12352202

PubChem Substance ID:

24894857

NACRES:

NA.77

MDL number:

MFCD00133350

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Product Name

Fumonisin B₂ from Fusarium moniliforme, sphingosine N-acyltransferase inhibitor

biological source

Fusarium sp. (Fusarium moniliforme)

Quality Level

100

assay

≥96% (TLC)

form

powder

solubility

methanol: 10 mg/mL, clear, colorless to faintly yellow

storage temp.

−20°C

SMILES string

CCCCC(C)C(OC(=O)CC(CC(O)=O)C(O)=O)C(CC(C)CCCCCCC(O)CC(O)C(C)N)OC(=O)CC(CC(O)=O)C(O)=O

InChI

1S/C34H59NO14/c1-5-6-12-21(3)32(49-31(43)18-24(34(46)47)16-29(40)41)27(48-30(42)17-23(33(44)45)15-28(38)39)14-20(2)11-9-7-8-10-13-25(36)19-26(37)22(4)35/h20-27,32,36-37H,5-19,35H2,1-4H3,(H,38,39)(H,40,41)(H,44,45)(H,46,47)

InChI key

UXDPXZQHTDAXOZ-UHFFFAOYSA-N

Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

General description

Fumonisin B₂ (FB₂) is a diester of tricarballylic acid and polyhydric alcohols.. Fumonisins B₂ (FB₂) does not have one or more hydroxyl groups at the C5 or C10 positions.

Mycotoxin originally isolated from Fusarium sp, which grows on corn. Produces neural tube defects and craniofacial abnormalities in fetuses. Many strains of Aspergillus niger growing naturally on grapes are capable of producing fumonisin B₂, so it is now a concern for human consumption of grapes, raisins, and wine.

Application

Fumonisin B₂ (FB₂) from Fusarium moniliforme has been used:

as a standard for the detection of FB₂ by high performance liquid chromatography (HPLC) in corn based food products
used as standard in the determination of fumonisin B1 and B2 in corn and corn-based products by high-performance liquid chromatography
as a standard in the determination of mycotoxins by HPLC

Biochem/physiol Actions

Inhibitor of sphingosine N-acyltransferase. Blocks the formation of ceramide from sphingosine.

pictograms

GHS08

signalword

Warning

hcodes

H351

pcodes

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Carc. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

高风险级别生物产品--毒素类产品

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Selected mycotoxins affecting animal and human health

Handbook of Toxicologic Pathology, 699 (2002)

Determination of fumonisin B1 and B2 in corn and corn-based products in Turkey by high-performance liquid chromatography

OMURTAG GZ

Journal of Food Protection, 64, 1072-1075 (2001)

Toxicokinetics of fumonisin B2 in ducks and turkeys.

I Benlashehr et al.

Poultry science, 90(8), 1671-1675 (2011-07-15)

Two extraction steps combined with HPLC with fluorescence detection were developed to determine the toxicokinetics of fumonisin B(2) (FB(2)) in ducks and turkeys. The limit of quantification of the method was 25 ng of FB(2)/mL. The mean extraction was 63%.

Visualisation and quantification of fumonisins bound by lactic acid bacteria isolates from traditional African maize-based fermented cereals, ogi and mahewu.

Pranitha Dawlal et al.

Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 36(2), 296-307 (2019-01-25)

Consumption of fumonisin-contaminated foods has a negative influence on the health of humans (carcinogen; oesophageal cancer in Eastern Cape in South Africa). Lactic acid bacteria (LAB) have emerged as a promising natural detoxification agent against mycotoxins. The aim of this

Cytotoxicity of Mycotoxins Frequently Present in Aquafeeds to the Fish Cell Line RTGill-W1.

Elena Bernal-Algaba et al.

Toxins, 13(8) (2021-08-27)

In the last decades, the aquaculture industry has introduced plant-based ingredients as a source of protein in aquafeeds. This has led to mycotoxin contaminations, representing an ecological, health and economic problem. The aim of this study was to determine in

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Global Trade Item Number

SKU	GTIN
F3771-10MG	04061833617182
F3771-1MG	04061833617199

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