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F3917

Forskolin

Name: Forskolin
Brand: SIGMA

For use in molecular biology applications

Synonym(s):

7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one, Coleonol, Colforsin

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About This Item

Empirical Formula (Hill Notation):

C₂₂H₃₄O₇

CAS Number:

66575-29-9

Molecular Weight:

410.50

UNSPSC Code:

12352200

NACRES:

NA.52

PubChem Substance ID:

24894799

EC Number:

266-410-9

Beilstein/REAXYS Number:

1692716

MDL number:

MFCD00082317

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

200

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biological source

Coleus forskohlii

Quality Level

200

description

for activation of T cells

product line

BioReagent

assay

≥98% (HPLC)

form

powder

mol wt

410.50 g/mol

color

white to off-white

solubility

ethanol: soluble

suitability

suitable for inhibits interleukin 2 (IL-2) production in Jurkat cells

storage temp.

room temp

SMILES string

CC(=O)O[C@H]1[C@@H](O)[C@H]2C(C)(C)CC[C@H](O)[C@]2(C)[C@@]3(O)C(=O)C[C@@](C)(O[C@]13C)C=C

InChI

1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1

InChI key

OHCQJHSOBUTRHG-KGGHGJDLSA-N

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General description

Forskolin is a cell permeable diterpenoid isolated from Coleus forskohlii.

Biochem/physiol Actions

Cell-permeable diterpenoid that possesses anti-hypertensive, positive inotropic, and adenylyl cyclase activating properties. Many of its biological effects are due to its activation of adenylyl cyclase and the resulting increase in intracellular cAMP concentration. Forskolin effects calcium currents and inhibits MAP kinase.

pictograms

GHS07

signalword

Warning

hcodes

H312

pcodes

P280 - P302 + P352 + P312 - P362 + P364 - P501

Hazard Classifications

Acute Tox. 4 Dermal

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

0000519429

0000497468

0000497469

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Long-distance axonal regeneration in the transected adult rat spinal cord is promoted by olfactory ensheathing glia transplants.

A Ramón-Cueto et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 18(10), 3803-3815 (1998-06-06)

The lack of axonal regeneration in the injured adult mammalian spinal cord leads to permanent functional impairment. To induce axonal regeneration in the transected adult rat spinal cord, we have used the axonal growth-promoting properties of adult olfactory bulb ensheathing

Seminiferous cord formation is regulated by hedgehog signaling in the marsupial.

Jin Wei Chung et al.

Biology of reproduction, 86(3), 80-80 (2011-12-03)

The signaling molecule DHH, secreted by Sertoli cells, has essential regulatory functions in testicular differentiation. DHH is required for the differentiation of peritubular myoid cells that line the seminiferous cords and steroidogenic Leydig cells. The testicular cords in Dhh-null male

Hydroxychloroquine restores trophoblast fusion affected by antiphospholipid antibodies.

T Marchetti et al.

Journal of thrombosis and haemostasis : JTH, 12(6), 910-920 (2014-03-25)

Obstetric antiphospholipid syndrome (APS) is defined by pregnancy complications associated with antiphospholipid antibodies (aPL). The mechanisms of the pathogenic effects of aPL in pregnancy are poorly understood. Toll-like receptors (TLR) have been implicated previously in APS. The aims of our

Enhanced chondrogenesis of induced pluripotent stem cells from patients with neonatal-onset multisystem inflammatory disease occurs via the caspase 1-independent cAMP/protein kinase A/CREB pathway.

Koji Yokoyama et al.

Arthritis & rheumatology (Hoboken, N.J.), 67(1), 302-314 (2014-10-11)

Neonatal-onset multisystem inflammatory disease (NOMID) is a dominantly inherited autoinflammatory disease caused by NLRP3 mutations. NOMID pathophysiology is explained by the NLRP3 inflammasome, which produces interleukin-1β (IL-1β). However, epiphyseal overgrowth in NOMID is resistant to anti-IL-1 therapy and may therefore

Spreading depression sends microglia on Lévy flights.

Yelena Y Grinberg et al.

PloS one, 6(4), e19294-e19294 (2011-05-05)

Spreading depression (SD) is thought to cause migraine aura, and perhaps migraine, and includes a transient loss of synaptic activity preceded and followed by increased neuronal excitability. Activated microglia influence neuronal activity and play an important role in homeostatic synaptic

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Protocols

Forskolin-Induced Swelling Assays using Millicell^® Microwell Plates

Learn how to cultivate similar-sized iPSC-derived colon organoids using Millicell^® Microwell plates and perform a forskolin-induced swelling assay.

Global Trade Item Number

SKU	GTIN
F3917-10MG	04061833617342
F3917-25MG	04061833617359

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