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Merck
CN

F6127

Fludrocortisone acetate

synthetic, ≥98%, glucocorticoid activity, powder

Synonym(s):

9α-Fluoro-11β,17α,21-trihydroxy-4-pregnene-3,20-dione acetate, 9-Fluorocortisol acetate, 9-Fluorohydrocortisone acetate

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About This Item

Empirical Formula (Hill Notation):
C23H31FO6
CAS Number:
514-36-3
Molecular Weight:
422.49
EC Number:
208-180-4
MDL number:
MFCD00864160
UNSPSC Code:
12352200
PubChem Substance ID:
24894899
NACRES:
NA.77

Key Documents

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Product Name

Fludrocortisone acetate, ≥98%

biological source

synthetic

Quality Level

100

sterility

non-sterile

Assay

≥98%

form

powder

solubility

acetone: 50 mg/mL, clear, colorless to light yellow

shipped in

ambient

storage temp.

room temp

SMILES string

CC(=O)OCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C

InChI

1S/C23H31FO6/c1-13(25)30-12-19(28)22(29)9-7-16-17-5-4-14-10-15(26)6-8-20(14,2)23(17,24)18(27)11-21(16,22)3/h10,16-18,27,29H,4-9,11-12H2,1-3H3/t16-,17-,18-,20-,21-,22-,23-/m0/s1

InChI key

SYWHXTATXSMDSB-GSLJADNHSA-N

Gene Information

human ... NR3C2(4306)

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General description

Fludrocortisone acetate is secreted by adrenal cortex. It increases the reabsorption of sodium and secretion of potassium and hydrogen. Fludrocortisone is used to treat cerebral salt wasting syndrome and adrenal insufficiency. Fludrocortisone improves the sensitivity of blood vessels to catecholamines and increases the blood volume.

Biochem/physiol Actions

Fludrocortisone acetate is a synthetic corticosteroid with more mineralocorticoid than glucocorticoid activity.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Warning

Hazard Statements

H302,H361

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
BCCG3165
BCBV4395
BCBR1170V
BCBR1170
BCBQ4707V

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G G Krishna et al.
Kidney international, 43(5), 1097-1103 (1993-05-01)
Potassium depletion induced by dietary potassium restriction causes sodium retention while potassium supplementation augments urinary sodium excretion. The role of external potassium balance in modulating mineralocorticoid-induced sodium retention in humans is unknown. Accordingly, eight healthy subjects were studied at the
Autonomic Neurology (2014)
Stéphane Gibaud et al.
International journal of pharmaceutics, 269(2), 491-508 (2004-01-07)
Substitutive hormonal therapies have to be administered for long periods. Thus, the development of sustained-release forms, as microparticle suspensions, is interesting in order to improve patient compliance by reducing dosing frequencies and side effects. The aim of this work was
Ichiro Nakagawa et al.
Cerebrovascular diseases (Basel, Switzerland), 35(2), 131-137 (2013-02-15)
Hyponatremia is a common complication occurring in one third of patients after subarachnoid hemorrhage (SAH). One mechanism that likely mediates the development of hyponatremia in SAH is cerebral salt wasting syndrome (CSWS), which induces natriuresis and reduces total blood volume
Clinical Pharmacology Made Incredibly Easy! (2009)
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