F7057
Folate Receptor 2 human
recombinant, expressed in CHO cells, ≥95% (SDS-PAGE)
Synonym(s):
FOLR2, Folate Receptor beta
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.56
biological source
human
Quality Level
recombinant
expressed in CHO cells
Assay
≥95% (SDS-PAGE)
form
lyophilized
impurities
≤1.0 EU/μg endotoxin
UniProt accession no.
application(s)
cell analysis
storage temp.
−20°C
Gene Information
human ... FOLR2(2350)
Application
Folate Receptor 2 has been used in studies of the treatment of rheumatoid arthritis (RA) with Methotrexate (MTX). These studies have focused on transport of MTX through folate receptor 2 in RA synovial macrophages.
Biochem/physiol Actions
Folate Receptor 2 is a 38kDa protein that has a high affinity for folic acid and mediates 5-methyltetrahydrofolate to the inside of the cell.
Physical form
Lyophilized from PBS
Preparation Note
Reconstitute at 100 μg/ mL in PBS
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Andreas Wunder et al.
Journal of immunology (Baltimore, Md. : 1950), 170(9), 4793-4801 (2003-04-23)
We reported recently that albumin is a suitable drug carrier for targeted delivery of methotrexate (MTX) to tumors. Due to pathophysiological conditions in neoplastic tissue, high amounts of albumin accumulate in tumors and are metabolized by malignant cells. MTX, covalently
C Fiehn
Clinical and experimental rheumatology, 28(5 Suppl 61), S40-S45 (2010-11-26)
Methotrexate (MTX) plays a pivotal role in the treatment of rheumatoid arthritis (RA). The transport mechanisms with which MTX reaches is target after application are an important part of MTX pharmacology and its concentration in target tissue such as RA
N Nakashima-Matsushita et al.
Arthritis and rheumatism, 42(8), 1609-1616 (1999-08-14)
To investigate the expression of folate receptors (FR) and reduced folate carrier (RFC) and determine their relevance to methotrexate (MTX) transport in synovial mononuclear cells (SMC) from patients with rheumatoid arthritis (RA). Levels of FR and RFC messenger RNA (mRNA)
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