F7932
Famciclovir
≥98% (HPLC)
Synonym(s):
2-(2-(2-Amino-9H-purin-9-yl)ethyl)-1,3-propanediol diacetate ester, BRL 42810
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About This Item
Empirical Formula (Hill Notation):
C14H19N5O4
CAS Number:
Molecular Weight:
321.33
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
desiccated
Quality Segment
assay
≥98% (HPLC)
form
solid
storage condition
desiccated
solubility
DMSO: ≥10 mg/mL
originator
Novartis
storage temp.
2-8°C
SMILES string
CC(=O)OCC(CCn1cnc2cnc(N)nc12)COC(C)=O
InChI
1S/C14H19N5O4/c1-9(20)22-6-11(7-23-10(2)21)3-4-19-8-17-12-5-16-14(15)18-13(12)19/h5,8,11H,3-4,6-7H2,1-2H3,(H2,15,16,18)
InChI key
GGXKWVWZWMLJEH-UHFFFAOYSA-N
Application
Famciclovir is used in herpes virus infections and hepatitis B drug development research. It may be used as a reference compound. Famciclovir may be used to study the factors that control its conversion into penciclovir and other metabolites.
Biochem/physiol Actions
Famciclovir is an Antiviral; Guanine analog used to treat herpesvirus infections.
Famciclovir is an antiretroviral guanosine analog used to treat herpesvirus infections and hepatitis B. Famciclovir is rapidly converted to penciclovir. Viral thymidine kinase phosphorylates penciclovir to a monophosphate form that celular kinases convert in turn to penciclovir triphosphate. Penciclovir triphosphate competitively inhibits viral DNA polymerase and thus viral replication. Prolonged administration can lead to resistance; it is often manifested as selection of pre-existing resistant strains with mutations in the reverse transcriptase domain of the DNA polymerase gene.
Features and Benefits
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Articles
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
Global Trade Item Number
| SKU | GTIN |
|---|---|
| F7932-50MG | 04061833234457 |
| F7932-10MG | 04061833234440 |