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Merck
CN

F8507

(±)-Fenfluramine hydrochloride

Synonym(s):

(±)-N-Ethyl-α-methyl-m-[trifluoromethyl]phenethylamine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C12H16F3N · HCl
CAS Number:
16105-77-4
Molecular Weight:
267.72
MDL number:
MFCD00058016
UNSPSC Code:
12352200
PubChem Substance ID:
24894965

Key Documents

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drug control

USDEA Schedule IV

application(s)

forensics and toxicology

SMILES string

Cl.CCNC(C)Cc1cccc(c1)C(F)(F)F

InChI

1S/C12H16F3N.ClH/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15;/h4-6,8-9,16H,3,7H2,1-2H3;1H

InChI key

ZXKXJHAOUFHNAS-UHFFFAOYSA-N

Gene Information

human ... HTR1D(3352), HTR2C(3358), SIGMAR1(10280)

Biochem/physiol Actions

Neurotoxic on prolonged administration or at high dosage; releases serotonin from axon terminals by a nonexocytotic mechanism; anorectic

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Precautionary Statements

P301 + P310

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
093K1065
024K1165
112K0643
077F0787
052K1359

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Y X Wang et al.
The Journal of pharmacology and experimental therapeutics, 291(3), 1008-1016 (1999-11-24)
Fenfluramine is an indirect agonist of 5-hydroxytryptamine (5-HT) receptors that acts by evoking 5-HT release and blocking 5-HT reuptake in neuronal cells. The current study compared the antinociceptive properties of fenfluramine with those of the tricyclic antidepressants amitriptyline and desipramine
Justin N Siemian et al.
British journal of pharmacology, 175(9), 1519-1534 (2018-02-17)
Although the antinociceptive efficacies of imidazoline I2 receptor agonists have been established, the exact post-receptor mechanisms remain unknown. This study tested the hypothesis that monoaminergic transmission is critical for I2 receptor agonist-induced antinociception. von Frey filaments were used to assess
J D Roth et al.
European journal of pharmacology, 373(2-3), 127-134 (1999-07-22)
Fenfluramine + phentermine was a widely used combination for weight loss. Fenfluramine and phentermine are believed to act via serotonin and catecholamines, respectively. To what extent these drugs interact has not been well-established. We compared the anorectic efficacy of a
Eileen K Sawyer et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 37(8), 1816-1824 (2012-03-22)
Acute SSRI (selective serotonin reuptake inhibitor) treatment has been shown to attenuate the abuse-related effects of cocaine; however, SSRIs have had limited success in clinical trials for cocaine abuse, possibly due to neurobiological changes that occur during chronic administration. In
Mediator scandal engulfs French compensation body.
Asher Mullard
Lancet (London, England), 381(9880), 1803-1803 (2013-05-30)
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