F8527
Monoclonal Anti-CD45−FITC/CD14-PE DUAL-TAG™ antibody produced in mouse
clone BRA-55/UCHM-1, purified immunoglobulin, buffered aqueous solution
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About This Item
UNSPSC Code:
12352203
MDL number:
biological source
mouse
conjugate
FITC conjugate, phycoerythrin (R-PE) conjugate
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
BRA-55/UCHM-1, monoclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
flow cytometry: 20 μL using 1 × 106 cells
isotype
IgG1/IgG2a
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
Gene Information
human ... CD14(929), PTPRC(5788)
Application
Monoclonal Anti-CD45-FITC/CD14-PE DUAL-TAG™ antibody is suitable for flow cytometry at a concentration of 20μL using 1×106 cells.
Biochem/physiol Actions
CD45 is a family of single chain transmembrane glycoproteins, consisting of different isoforms, which share a common large intracellular domain. It is abundantly present in leukocyte cell surface and belongs to a novel class of enzymes, the protein tyrosine phosphatases (PTPs). It plays an essential role in thymic selection and peripheral activation of T and B cells. It is associated with various signal transduction pathways. It may also accelerate the Src family tyrosine kinases activity. an important determinant of immune tolerance.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.
Legal Information
DUAL-TAG is a trademark of Sigma-Aldrich Co. LLC
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Datasheet
Calvin C K Yu et al.
Current directions in autoimmunity, 6, 61-88 (2002-11-01)
Mutations in a number of signaling components in mice can lead to strong autoimmune phenotypes. In some cases, these mutations likely compromise important feedback inhibitory pathways that downregulate antigen receptor signaling. For example, a deficiency of Lyn leads to a
B Tackenberg et al.
Autoimmunity, 36(2), 117-121 (2003-06-25)
In myasthenia gravis (MG), humoral and cellular immune mechanisms are involved in the autoimmune pathogenesis. In this study, we investigated the role of the CD45 molecule in MG, having recently reported an association in multiple sclerosis. CD45, a protein-tyrosine phophatase
I S Trowbridge et al.
Annual review of immunology, 12, 85-116 (1994-01-01)
CD45 is one of the most abundant leukocyte cell surface glycoproteins and is expressed exclusively upon cells of the hematopoietic system. Different isoforms of CD45 are generated by alternative splicing and are expressed in cell type-specific patterns on functional subpopulations