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F8758

Folic acid

Name: Folic acid
Brand: SIGMA

BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥97%

Synonym(s):

Pterylmonoglutamic acid, PteGlu, Pteroyl-L-glutamic acid, Vitamin M

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₁₉N₇O₆

CAS Number:

59-30-3

Molecular Weight:

441.40

NACRES:

NA.75

PubChem Substance ID:

24894973

eCl@ss:

34058014

UNSPSC Code:

12352205

EC Number:

200-419-0

MDL number:

MFCD00079305

Beilstein/REAXYS Number:

100781

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biological source

synthetic

Quality Level

300

product line

BioReagent

assay

≥97%

form

powder

mol wt

M_w 441.40 g/mol

technique(s)

cell culture | insect: suitable, cell culture | mammalian: suitable, cell culture | plant: suitable

color

dark yellow

solubility

1 M NaOH: soluble 50 mg/mL, clear to very slightly hazy, faintly yellow to dark yellow-orange

storage temp.

room temp

SMILES string

NC(N1)=NC(C2=C1N=CC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)=O

InChI

1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1

InChI key

OVBPIULPVIDEAO-LBPRGKRZSA-N

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Related Categories

Biochemicals

Cell Culture & Analysis

Cell Culture Media & Buffers

Cell Culture Supplements & Reagents

Molecular Biology & Functional Genomics

General description

Folic acid (FA)/pterylmonoglutamic acid helps to block neural tube defects (NTDs).

Application

Folic acid has been used:

to study the role of vitamins and amino acids on hybridoma growth and monoclonal antibody production
in cells and treatments
in perforin gene targeting using the CRISPR/Cas gene editing approach

Biochem/physiol Actions

A nutritional delivery form of folate. Folic acid and its derivatives are essential mediators of one-carbon metabolism within cells.

Storage Class

11 - Combustible Solids

wgk

WGK 1

ppe

Eyeshields, Gloves, type N95 (US)

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Bone marrow derived mesenchymal stem cells ameliorate inflammatory response in an in vitro model of familial hemophagocytic lymphohistiocytosis 2

Sevim H, et al.

Stem Cell Research & Therapy, 9(1), 198-198 (2018)

Folic acid handling by the human gut: implications for food fortification and supplementation

Patanwala I, et al.

American Journal of Clinical Nutrition, 100(2), 593-599 (2014)

Periconceptional folic acid supplementation and the risk of preterm births in China: a large prospective cohort study

Li Z, et al.

International Journal of Epidemiology, 43(4), 1132-1139 (2014)

Reduced expression of galectin-9 contributes to a poor outcome in colon cancer by inhibiting NK cell chemotaxis partially through the Rho/ROCK1 signaling pathway

Wang Y, et al.

PloS one, 11(3), e0152599-e0152599 (2016)

The role of vitamins and amino acids on hybridoma growth and monoclonal antibody production

Ducommun P, et al.

Cytotechnology, 37(2), 65-73 (2001)

View All Related Papers

Articles

Folic Acid and Tetrahydrofolates in Cell Culture

Explore folic acid importance in serum-free eukaryotic cell cultures, including CHO cells, and its role in media supplementation.

Global Trade Item Number

SKU	GTIN
F8758-25G	04061833620977
F8758-5G	04061833621011

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