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F8932

Fatostatin hydrobromide

Name: Fatostatin hydrobromide
Brand: SIGMA

≥98% (HPLC), powder

Synonym(s):

25B11 hydrobromide, 4-[4-(4-methylphenyl)-2-thiazolyl]-2-propylpyridine hydrobromide, Fatostatin A hydrobromide; 2-(2-propylpyridin-4-yl)-4-p-tolylthiazole hydrobromide

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₁₈N₂S·HBr

CAS Number:

298197-04-3

Molecular Weight:

375.33

MDL number:

MFCD00760867

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

powder

Storage condition:

desiccated

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Properties

Quality Segment

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

light yellow to yellow

solubility

DMSO: ≥10 mg/mL

storage temp.

2-8°C

SMILES string

[s]1c(nc(c1)c3ccc(cc3)C)c2cc(ncc2)CCC.Br

InChI

1S/C18H18N2S.BrH/c1-3-4-16-11-15(9-10-19-16)18-20-17(12-21-18)14-7-5-13(2)6-8-14;/h5-12H,3-4H2,1-2H3;1H

InChI key

RJCFNQZVFUMORB-UHFFFAOYSA-N

Description

General description

Fatostatin is a non-sterol diarylthiazole derivative. It prevents insulin-induced adipogenesis and lowers the amounts of fatty acid, triglyceride and low-density lipoprotein. Fatostatin has anti tumor and antimitotic properties.

Application

Fatostatin hydrobromide has been used:

to study its anti-cancer activity and effects on mitotic microtubule spindle
to study its effects on stomatal development
to prevent SREBP cleavage-activating protein (SCAP)-mediated escort of sterol regulatory element-binding proteins (SREBPs)

Biochem/physiol Actions

Fatostatin hydrobromide is an SREBP inhibitor.

Fatostatin hydrobromide is an SREBP inhibitor. Fatostatin hydrobromide inhibits fat production and lowers glucose levels in mice by inhibiting SREBP (Sterol Regulatory Element Binding Proteins).

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Global Trade Item Number

SKU	GTIN
F8932-25MG	04061832632049
F8932-5MG	04061832632056