G0503
Karaya gum
Synonym(s):
Gum karaya from sterculia tree, Tragacanth Indian
biological source
plant fluids (Gum karaya)
form
powder
color
faint yellow to brown
storage temp.
room temp
Quality Level
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Application
Karaya gum may be used for the development of gastro intestinal tract drug delivery vehicles, mucoadhesive sustained release drug delivery and noneffervescent floating drug delivery systems in combination with alginate.
Other Notes
Believed to be a partially acetylated polymer of galactose, rhamnose, and glucuronic acid with a M.W. of approx. 9,500,000.
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Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
植物油/植物胶产品
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S Singh et al.
Current drug delivery, 4(4), 269-275 (2007-11-06)
The present investigation concerns the development of floating matrix tablets of metoclopramide hydrochloride (MHCl) for improving its bioavailability by prolonging gastric residence time. Floating matrix tablets (FMT) of MHCl were prepared using the polymers guar gum (GG), karaya gum (KG)
Sadia Afrose et al.
Nutrition research (New York, N.Y.), 29(5), 350-354 (2009-06-27)
Different sources of saponins are known to have hypocholesterolemic activity with varying degrees of efficacy. We hypothesize that karaya root saponin would efficiently reduce cholesterol. The aim of this study is to examine the comparative hypocholesterolemic effect of karaya root
Anil Getyala et al.
Current drug delivery, 10(5), 620-629 (2013-01-05)
The aim of the work is to modify the solubility and bioavailability of Losartan potassium, by employing noneffervescent floating drug delivery (tablet dosage forms). Non-effervescent systems are a type of floating drug delivery systems, that have been used to boost
Baljit Singh et al.
International journal of biological macromolecules, 43(2), 142-150 (2008-05-27)
The present paper deals with the modification of the sterculia gum with methacrylic acid (MAAc) to hydrogels for use in drug delivery. The hydrogels were characterized by SEMs, FTIR and swelling studies. The release dynamics of model anti-ulcer drug (ranitidine
Kimberly A Foster et al.
International journal of pharmaceutics, 434(1-2), 406-412 (2012-06-14)
Target validation or demonstration of efficacy requires adequate in vivo exposure of tool molecules to determine their activity in order to validate the model or show the potential usefulness of the pharmacophore. Early discovery work is often carried out with
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