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G0544

GR 103691

Name: GR 103691
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

4′-Acetyl-N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-[1,1′-biphenyl]-4-carboxamide

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About This Item

Empirical Formula (Hill Notation):

C₃₀H₃₅N₃O₃

CAS Number:

162408-66-4

Molecular Weight:

485.62

NACRES:

NA.77

PubChem Substance ID:

24724488

UNSPSC Code:

12352200

MDL number:

MFCD00936840

Assay:

≥98% (HPLC)

Form:

solid

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Properties

Quality Segment

100

assay

≥98% (HPLC)

form

solid

color

white

solubility

DMSO: soluble >5 mg/mL at 60 °C

originator

GlaxoSmithKline

storage temp.

2-8°C

SMILES string

COc1ccccc1N2CCN(CCCCNC(=O)c3ccc(cc3)-c4ccc(cc4)C(C)=O)CC2

InChI

1S/C30H35N3O3/c1-23(34)24-9-11-25(12-10-24)26-13-15-27(16-14-26)30(35)31-17-5-6-18-32-19-21-33(22-20-32)28-7-3-4-8-29(28)36-2/h3-4,7-16H,5-6,17-22H2,1-2H3,(H,31,35)

InChI key

JARNORYOPMINDY-UHFFFAOYSA-N

Gene Information

rat ... Htr1a(24473)

Description

Application

GR 103691 has been used as a D3 receptor antagonist to test its:

inducing effect on prepulse inhibition (PPI)
suppressive effect of motor behavior in rats
inhibitory effect on chemotaxis in newly excysted juvenile C. sinensis (CsNEJs)

Biochem/physiol Actions

D₃ dopamine receptor antagonist.

GR 103691 increases the monosynaptic “stretch” reflex (MSR) amplitude in mice by its potent D3 receptor antagonist functionality. It inhibits the PD 128,907 mediated γ-aminobutyric acid (GABA) release.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from GlaxoSmithKline

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c