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Merck
CN

G0668

GW2974

≥98% (HPLC), solid

Synonym(s):

N4-(1-Benzyl-1H-indazol-5-yl)-N6,N6-dimethyl-pyrido­[3,4-d]­pyrimidine-4,6-diamine

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About This Item

Empirical Formula (Hill Notation):
C23H21N7
CAS Number:
202272-68-2
Molecular Weight:
395.46
NACRES:
NA.77
PubChem Substance ID:
24278451
UNSPSC Code:
51111800
MDL number:
MFCD04974495
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100

Key Documents

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Product Name

GW2974, ≥98% (HPLC), solid

InChI key

DYYZXRCFCVDSKD-UHFFFAOYSA-N

SMILES string

CN(C)c1cc2c(Nc3ccc4n(Cc5ccccc5)ncc4c3)ncnc2cn1

InChI

1S/C23H21N7/c1-29(2)22-11-19-20(13-24-22)25-15-26-23(19)28-18-8-9-21-17(10-18)12-27-30(21)14-16-6-4-3-5-7-16/h3-13,15H,14H2,1-2H3,(H,25,26,28)

assay

≥98% (HPLC)

form

solid

color

yellow

solubility

DMSO: ≥20 mg/mL

originator

GlaxoSmithKline

Quality Level

100

Gene Information

human ... EGFR(1956), ERBB2(2064)

Related Categories

Biochem/physiol Actions

Potent and selective dual inhibitor of EGFR (IC50 = 0.016 mM) and ErbB-2 receptor tyrosine kinase.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from Glaxo­Smith­Kline

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
019K4612
019K4610
012K47051
012K4705

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S Agarwal et al.
British journal of cancer, 100(6), 941-949 (2009-02-26)
There is a pressing need to identify new drug targets and novel approaches for treatment of non-small-cell lung carcinoma (NSCLC). Members of the epidermal growth factor receptor (EGFR) and Met receptor families have been identified as important molecular targets for
Keli Kolegraff et al.
Molecular biology of the cell, 22(8), 1121-1134 (2011-02-18)
Desmocollin-2 (Dsc2) and desmoglein-2 (Dsg2) are transmembrane cell adhesion proteins of desmosomes. Reduced expression of Dsc2 has been reported in colorectal carcinomas, suggesting that Dsc2 may play a role in the development and/or progression of colorectal cancer. However, no studies
Hauke Busch et al.
Molecular systems biology, 4, 199-199 (2008-07-03)
Translation of large-scale data into a coherent model that allows one to simulate, predict and control cellular behavior is far from being resolved. Assuming that long-term cellular behavior is reflected in the gene expression kinetics, we infer a dynamic gene

Articles

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Related Content

Data Sheet - G0668

Instructions

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