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Merck
CN

G1794

GAP-27

≥97% (HPLC)

Synonym(s):

Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile

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About This Item

Empirical Formula (Hill Notation):
C60H102N15O17
CAS Number:
198284-64-9
Molecular Weight:
1305.54
UNSPSC Code:
12352202
NACRES:
NA.32
MDL number:
MFCD11045577

Key Documents

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Product Name

GAP-27, ≥97% (HPLC)

form

powder

SMILES string

N1([C@@H](CCC1)C(=O)N[C@@H]([C@H](O)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@H](O)C)C(=O)N[C@@H]([C@H](CC)C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@H](CC)C)C(=O)N[C@@H]([C@H](CC)C)C(=O)O)C(=O)[C@@H](NC(=O)[C@@H](N)CO)CCCNC(=N)N

InChI

1S/C60H101N15O17/c1-9-31(4)44(54(86)69-41(29-36-19-13-12-14-20-36)52(84)70-45(32(5)10-2)55(87)72-46(59(91)92)33(6)11-3)71-57(89)48(35(8)78)73-51(83)38(21-15-16-26-61)66-50(82)39(24-25-43(79)80)67-56(88)47(34(7)77)74-53(85)42-23-18-28-75(42)58(90)40(22-17-27-65-60(63)64)68-49(81)37(62)30-76/h12-14,19-20,31-35,37-42,44-48,76-78H,9-11,15-18,21-30,61-62H2,1-8H3,(H,66,82)(H,67,88)(H,68,81)(H,69,86)(H,70,84)(H,71,89)(H,72,87)(H,73,83)(H,74,85)(H,79,80)(H,91,92)(H4,63,64,65)/t31-,32-,33-,34+,35+,37-,38-,39-,40-,41-,42-,44-,45-,46-,47-,48-/m0/s1

InChI key

SXRAPDIXXYFGJG-MDAHIHQXSA-N

biological source

human

assay

≥97% (HPLC)

packaging

pkg of 2 mg

technique(s)

cell culture | mammalian: suitable

solubility

water: soluble 1.00-1.02 mg/mL, clear, colorless

UniProt accession no.

P35212

shipped in

ambient

storage temp.

−20°C

Quality Level

200

Gene Information

human ... GJA4(2701)

Related Categories

Application

GAP-27 has been used as a blocking peptide for Cx43 (connexin 43) gap junctions in FDC (follicular dendritic cells)-B cell cultures.

Biochem/physiol Actions

GAP-27 shares homology with a region of extracellular loops of connexins, and hence, is thought to inhibit junctions formed by the connexins Cx32, Cx40 and Cx43. It highly hinders co-operative cell-cell interactions including the synergized beating of embryonic cardiomyocytes. This peptide reduces osteoclastic activity and survival rates. This peptide significantly reduces acetylcholine-mediated hyperpolarization of smooth muscle cells.
Inhibitor of gap junction signaling in endothelial cells.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000140634
0000140634
128M4798V
018M4863V
057M4858V

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Hajnalka Rajnai et al.
Journal of immunology research, 2015, 528098-528098 (2015-03-31)
Follicular dendritic cells (FDC) show homo- and heterocellular metabolic coupling through connexin 43 (Cx43) gap junctions and support B cell selection and maturation in germinal centers. In follicular lymphomas B cells escape apoptosis while FDC develop abnormally. Here we tested
J Ilvesaro et al.
BMC musculoskeletal disorders, 2, 10-10 (2001-12-19)
Bone remodelling is dependent on the balance between bone resorbing osteoclasts and bone forming osteoblasts. We have shown previously that osteoclasts contain gap-junctional protein connexin-43 and that a commonly used gap-junctional inhibitor, heptanol, can inhibit osteoclastic bone resorption. Since heptanol
Shaun L Sandow et al.
Circulation research, 90(10), 1108-1113 (2002-06-01)
The nature of the vasodilator endothelium-derived hyperpolarizing factor (EDHF) is controversial, putatively involving diffusible factors and/or electrotonic spread of hyperpolarization generated in the endothelium via myoendothelial gap junctions (MEGJs). In this study, we investigated the relationship between the existence of
Wenru Su et al.
Journal of immunology (Baltimore, Md. : 1950), 203(6), 1436-1446 (2019-08-20)
Therapeutic manipulation of regulatory T cells (Tregs) has been regarded as a promising approach for the treatment of immune disorders. However, a better understanding of the immunomodulatory mechanisms of Tregs and new safe and effective methods to improve the therapeutic

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