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Merck
CN

G2761

Gly-Pro-7-amido-4-methylcoumarin hydrobromide

dipeptidylpeptidase IV substrate

Synonym(s):

Gly-Pro-AMC

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About This Item

Empirical Formula (Hill Notation):
C17H19N3O4 · HBr
CAS Number:
115035-46-6
Molecular Weight:
410.26
NACRES:
NA.32
PubChem Substance ID:
24895103
UNSPSC Code:
12352204
MDL number:
MFCD00152092

Key Documents

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Product Name

Gly-Pro-7-amido-4-methylcoumarin hydrobromide, dipeptidylpeptidase IV substrate

InChI

1S/C17H19N3O4.BrH/c1-10-7-16(22)24-14-8-11(4-5-12(10)14)19-17(23)13-3-2-6-20(13)15(21)9-18;/h4-5,7-8,13H,2-3,6,9,18H2,1H3,(H,19,23);1H/t13-;/m0./s1

SMILES string

Br.CC1=CC(=O)Oc2cc(NC(=O)[C@@H]3CCCN3C(=O)CN)ccc12

InChI key

PASXTQMFJRHMLJ-ZOWNYOTGSA-N

assay

≥97% (TLC)

form

powder

solubility

water: 50 mg/mL, clear, colorless to light yellow

storage temp.

−20°C

Quality Level

200

Application

Gly-Pro-7-amido-4-methylcoumarin hydrobromide has been used as a substrate for determining the dipeptidylpeptidase IV (DPPIV) activity of the extract of Allophylus cominia Sw.

General description

Substrate for dipeptidylaminopeptidase IV.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000446245
0000446245
0000349705
0000349705
0000295820

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Fluorescence assay of x-prolyl dipeptidyl-aminopeptidase activity with a new fluorogenic substrate.
T Kato et al.
Biochemical medicine, 19(3), 351-359 (1978-06-01)
In vitro anti-diabetic activity of flavonoids and pheophytins from Allophylus cominia Sw. on PTP1B, DPPIV, alpha-glucosidase and alpha-amylase enzymes
Semaan DG, et al.
Journal of Ethnopharmacology, 203, 39-46 (2017)
Sandy Theysgeur et al.
Molecules (Basel, Switzerland), 26(1) (2021-01-06)
Like their owners, dogs and cats are more and more affected by overweight and obesity-related problems and interest in functional pet foods is growing sharply. Through numerous studies, fish protein hydrolysates have proved their worth to prevent and manage obesity-related
Muhammed Majeed et al.
Journal of the science of food and agriculture, 100(2), 509-516 (2019-09-06)
Emblica officinalis, known as amla in Ayurveda, has been used as a folk medicine to treat numerous pathological conditions, including diabetes. However, the novel extract of E. officinalis fruit extract (amla fruit extract, AFE, Saberry®) containing 100 g kg-1 β-glucogallin along with

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