Anti-Gravin antibody, Mouse monoclonal

Monoclonal Anti-Gravin (mouse IgG2a isotype) is derived from the hybridoma JP74 produced by the fusion of mouse myeloma cells (X63Ag8.653) and splenocytes from BALB/c mice immunized with fractionated membrane cortex proteins from human neurons [cell lines NT2-N and SK-N-BE(2)]. Gravin protein is a myristoylated high molecular weight cytoplasmic protein expressed in endothelial cells, cultured fibroblasts and osteosarcoma cells and highly expressed in the brain.

fractionated membrane cortex proteins from human neuron cell lines NT2-N and SK-N-BE(2).

Anti-Gravin antibody has been used in western blotting immunofluorescence.

Monoclonal Anti-Gravin antibody is suitable for use in immunoblotting (using mpkCCD cells ). The product may also be used for immunocytochemistry and immunoprecipitation.

Gravin (or AKAP12) is a scaffolding kinase that functions as a tumor suppressor. This kinase interacts with PKC, PKA and other cell cycle signaling proteins to modulate cell division, growth, differentiation and inflammatory responses. The expression of gravin isoforms (α, β, and γ) is regulated by tissue-specific promoters. Gravin also acts as an autoantigen in myasthenia gravis patients .

Monoclonal Anti-Gravin antibody is specific for human, rat and mouse gravin (approx. 300 kDa).

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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