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G4535

[D-Lys³]-GHRP-6

Name: [<SC>D</SC>-Lys<SUP>3</SUP>]-GHRP-6
Brand: SIGMA

synthetic, lyophilized powder

Synonym(s):

[His¹, D-Lys³, Lys⁶]-GHRP, His-D-Trp-D-Lys-Trp-D-Phe-Lys-NH₂, [D-Lys³]-Growth Hormone Releasing Peptide 6

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About This Item

NACRES:

NA.32

PubChem Substance ID:

329799930

UNSPSC Code:

12352209

MDL number:

MFCD00214665

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biological source

synthetic

Quality Level

200

form

lyophilized powder

UniProt accession no.

P01286

storage temp.

−20°C

SMILES string

NCCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](Cc4c[nH]c5ccccc45)NC(=O)[C@@H](N)Cc6c[nH]cn6)C(N)=O

InChI

1S/C49H63N13O6/c50-20-10-8-18-39(44(53)63)58-47(66)41(22-30-12-2-1-3-13-30)61-49(68)43(24-32-27-56-38-17-7-5-15-35(32)38)62-46(65)40(19-9-11-21-51)59-48(67)42(23-31-26-55-37-16-6-4-14-34(31)37)60-45(64)36(52)25-33-28-54-29-57-33/h1-7,12-17,26-29,36,39-43,55-56H,8-11,18-25,50-52H2,(H2,53,63)(H,54,57)(H,58,66)(H,59,67)(H,60,64)(H,61,68)(H,62,65)/t36-,39-,40+,41+,42+,43-/m0/s1

InChI key

MGSNWNLPMHXGDD-DFWOJPNQSA-N

Gene Information

human ... GHRH(2691)

General description

[D-Lys³]-GHRP6 (growth hormone releasing peptide 6) is a synthetic analog of the orexigenic peptide hormone called ghrelin.

Application

[D-Lys3]-GHRP-6 has been used:

to study its role in incretin dysfunction and hyperglycemia in cystic fibrosis
as an antagonist of growth hormone secretagogue receptor (GHS-R)
as ghrelin receptor antagonist to study the dose-dependent effects of intraduodenal ghrelin on the glucose infusion rate (GIR) during pancreatic-euglycemic clamp procedure (PECs)

[D-Lys³]-GHRP6 has been used-

to treat bovine somatotropes to determine the release of GH from treated cells and non-treated or control cells
for intraperitoneal injection to groups of broiler chicken to determine the effect on feed intake, weight gain, and feed conversion ratio

Biochem/physiol Actions

[D-Lys3]-GHRP-6, a selective growth-hormone secretagogue receptor (GHSR) antagonist displays pro-autophagic effects on skeletal muscle. It can be used to study the dependency of GHSR-1a signalling mediated by acylated ghrelin.

[D-Lys³]-GHRP6 (growth hormone releasing peptide 6) induces the secretion of growth hormone (GH). In the membrane of clonal GC somatotropes, this peptide elevates the number of functional voltage-gated Ca²⁺ and Na⁺ channels. Chronic treatment with this peptide causes an elevation in Na+ macroscopic current in bovine pituitary somatotropes in culture, which results in an increase in the release of GH.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

涉药品监管产品

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Upregulation of Voltage-Gated Calcium Channel Cav1.3 in Bovine Somatotropes Treated with Ghrelin

Salinas ZVM, et al.

Journal of signal transduction (2013)

Incretin dysfunction and hyperglycemia in cystic fibrosis: Role of acyl-ghrelin

Journal of Cystic Fibrosis, 18(4), 557-565 (2019)

Ghrelin increases growth hormone production and functional expression of NaV1.1 and Na V1.2 channels in pituitary somatotropes.

Adasue Magdaleno-Méndez et al.

Endocrine, 48(3), 929-936 (2014-08-26)

A variety of ion channels are expressed in the plasma membrane of somatotropes within the anterior pituitary gland. Modification of these channels is linked to intracellular Ca2+ levels and therefore to hormone secretion. Previous investigations have shown that the gut-derived

Incretin dysfunction and hyperglycemia in cystic fibrosis: Role of acyl-ghrelin.

Xingshen Sun et al.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 18(4), 557-565 (2019-02-11)

Insulin secretion is insufficient in cystic fibrosis (CF), even before diabetes is present, though the mechanisms involved remain unclear. Acyl-ghrelin (AG) can diminish insulin secretion and is elevated in humans with CF. We tested the hypothesis that elevated AG contributes

Growth hormone-releasing peptide (GHRP) binding to porcine anterior pituitary and hypothalamic membranes.

K Veeraragavan et al.

Life sciences, 50(16), 1149-1155 (1992-01-01)

The synthetic hexapeptide, His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 (GHRP, Growth Hormone-Releasing Peptide), has no structural similarities with any of the GH-releasing peptides known and its action in releasing GH is by a complementary but yet not clearly defined action on the pituitary as well

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Global Trade Item Number

SKU	GTIN
G4535-5MG	04061832676920

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