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G5003

Sigma-Aldrich

α-Glucosidase from Saccharomyces cerevisiae

greener alternative

Type I, lyophilized powder, ≥10 units/mg protein (using p-nitrophenyl α-D-glucoside as substrate.)

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Synonym(s):
α-D-Glucosidase, α-D-Glucoside glucohydrolase, Maltase from yeast
CAS Number:
9001-42-7
Enzyme Commission number:
3.2.1.20 (BRENDA, IUBMB)
EC Number:
232-604-7
MDL number:
MFCD00081321
NACRES:
NA.54

type

Type I

Quality Level

200

form

lyophilized powder

specific activity

≥10 units/mg protein (using p-nitrophenyl α-D-glucoside as substrate.)

contains

phosphate buffer salts and EDTA as balance

composition

Protein, ≥50%

greener alternative product characteristics

Waste Prevention
Design for Energy Efficiency
Learn more about the Principles of Green Chemistry.

UniProt accession no.

P38158
P53341

foreign activity

β-Glucosidase, α−galactosidase and β−galactosidase ≤0.1%

greener alternative category

, Enabling

relevant disease(s)

diabetes (management of non-insulin-dependent diabetes mellitus)

storage temp.

−20°C

Gene Information

bakers yeast ... MAL12(853209) , MAL32(852602)

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General description

We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product has been enhanced for energy efficiency and waste prevention when used in starch hydrolysis research. For more information see the article in biofiles.

Application

α-glucosidase is used for the determination of α-amylase and the synthesis of various 1′-O-sucrose and 1-O-fructose esters. It was also used in the measurement of glycosidase inhibition.
For the determination of α-amylase and the synthesis of various 1′-O-sucrose and 1-O-fructose esters

Biochem/physiol Actions

α-glucosidase hydrolyzes carbohydrates by acting on 1,4-α linkages. Inhibition of α-glucosidase is a prominent target in the management of non-insulin-dependent diabetes mellitus.
Hydrolysis of terminal, non-reducing 1→4-linked D-glucose residues with release of D-glucose.

Packaging

Sold on basis of p-nitrophenyl α-D-glucoside units.

Unit Definition

One unit will liberate 1.0 μmole of D-glucose from p-nitrophenyl α-D-glucoside per min at pH 6.8 at 37 °C.

Analysis Note

Protein determined by biuret.

Other Notes

View more information on enzymes for complex carbohydrate analysis at www.sigma-aldrich.com/enzymeexplorer

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Ivan Best et al.
Heliyon, 6(10), e05209-e05209 (2020-10-23)
Mauritia flexuosa L.f. is a palm tree which presents great morphological variability (morphotypes), represented mainly by the mesocarp color of its fruits. The objective of the study was to characterize the physicochemical and antioxidant properties of three morphotypes of Mauritia
Matusorn Wongon et al.
Heliyon, 6(3), e03458-e03458 (2020-03-11)
Long-term diabetic complications are exacerbated by post-prandial hyperglycemia which could be ameliorated by α-glucosidase inhibitor including oxyresveratrol. Puag-Haad is an aqueous extract from Artocarpus lakoocha Roxb. containing ~65% oxyresveratrol. Oxyresveratrol is an inhibitor of isolated yeast α-glucosidase enzyme but has
Gitishree Das et al.
International journal of nanomedicine, 14, 4741-4754 (2019-08-29)
Ipomoea batatas (L.) Lam.(Ib) has high content of various beneficial nutrients which helps in improving and maintaining human health. It is well known as a functional food and also a valuable source of unique natural products. It contains various phenolic
M Bianchi
Anatomischer Anzeiger, 169(5), 351-366 (1989-01-01)
In 13 horses from both sexes, between 5 months and 18 years of age, in good nutritional state, statistical evaluations of fat cell sizes were performed in 16 body regions. From direct and indirect measurements referred to the cell diameter
A D Baron
Diabetes research and clinical practice, 40 Suppl, S51-S55 (1998-09-18)
Fasting blood glucose level is usually used to diagnose diabetes, but is not a good predictor of postprandial hyperglycaemia, which is a more accurate measure of the metabolic defect underlying type 2 diabetes. Postprandial blood glucose levels may be elevated
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